Yan Jiang1, Jian-Ming Li, Huai-Qing Luo. 1. Department of Basic Medical Science, Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, PR China E-mail : 894269826@qq.com.
Abstract
BACKGROUND: Recent reports have shown that DLC-1 is widely expressed in normal tissues and is down- regulated in a wide range of human tumors, suggesting it may act as a tumor suppressor gene. We conducted a meta-analysis to determine the correlation between DLC-1 expression and clinicopathological characteristics in cancers. MATERIALS AND METHODS: A detailed literature search was made for relevant publications from PubMed, EMBASE, Cochrane library databases, Web of Science, CNKI. The methodological quality of the studies was also evaluated. Analyses of pooled data were performed and odds ratios (ORs) were calculated and summarized. RESULTS: Final analysis was performed of 1,815 cancer patients from 19 eligible studies. We observed that DLC- 1 expression was significantly lower in cancers than in normal tissues. DLC-1 expression was not found to be associated with tumor differentiation status. However, DLC-1 expression was obviously lower in advance stage than in early-stage cancers and was more down-regulated in metastatic than non-metastatic cancers. CONCLUSIONS: The results of our meta-analysis suggested that DLC-1 expression is significantly lower in cancers than in normal tissues. Aberrant DLC-1 expression may play an important role in cancer genesis and metastasis.
BACKGROUND: Recent reports have shown that DLC-1 is widely expressed in normal tissues and is down- regulated in a wide range of humantumors, suggesting it may act as a tumor suppressor gene. We conducted a meta-analysis to determine the correlation between DLC-1 expression and clinicopathological characteristics in cancers. MATERIALS AND METHODS: A detailed literature search was made for relevant publications from PubMed, EMBASE, Cochrane library databases, Web of Science, CNKI. The methodological quality of the studies was also evaluated. Analyses of pooled data were performed and odds ratios (ORs) were calculated and summarized. RESULTS: Final analysis was performed of 1,815 cancerpatients from 19 eligible studies. We observed that DLC- 1 expression was significantly lower in cancers than in normal tissues. DLC-1 expression was not found to be associated with tumor differentiation status. However, DLC-1 expression was obviously lower in advance stage than in early-stage cancers and was more down-regulated in metastatic than non-metastatic cancers. CONCLUSIONS: The results of our meta-analysis suggested that DLC-1 expression is significantly lower in cancers than in normal tissues. Aberrant DLC-1 expression may play an important role in cancer genesis and metastasis.
Authors: Norhazlina Abdul Wahab; Zahreena Othman; Noor Wahidah Mohd Nasri; Mohd Helmy Mokhtar; Siti Fatimah Ibrahim; Adila A Hamid; Raja Affendi Raja Ali; Norfilza Mohd Mokhtar Journal: Int J Environ Res Public Health Date: 2020-04-17 Impact factor: 3.390
Authors: Sheril June Ankasha; Mohamad Nasir Shafiee; Norhazlina Abdul Wahab; Raja Affendi Raja Ali; Norfilza Mohd Mokhtar Journal: Int J Environ Res Public Health Date: 2021-05-27 Impact factor: 3.390