Jeevanandham Madana1, Grégoire B Morand2, Abdulaziz Alrasheed2, Nathalie Gabra2, Frédérick Laliberté2, Luz Barona-Lleó1, Deeke Yolmo3, Martin J Black2, Khalil Sultanem4, Michael P Hier2. 1. Department of Otolaryngology - Head and Neck Surgery, Wayne State University, Detroit, Michigan. 2. Department of Otolaryngology - Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada. 3. Department of E.N.T, Darjeeling District Hospital, Darjeeling, India. 4. Department of Radiation Oncology, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Abstract
BACKGROUND: As the locoregional control rates in head and neck squamous cell carcinoma (HNSCC) have increased, these patients may suffer distant metastasis in a higher proportion of cases. Clinicopathological characteristics allowing prediction of high-risk profile would allow adapting posttreatment surveillance to individual risk. METHODS: A retrospective review of all patients with HNSCC treated at the Jewish General Hospital, McGill University, Montreal, Quebec, Canada, between 1999 and 2008 was conducted for this study. RESULTS: The study included 428 patients with a mean follow-up of 65 months (±SEM 1.7). Eighty patients (18.6%) developed pulmonary malignancy during follow-up. In multivariate Cox-regression analysis, locoregional failure and current smoking were associated with higher risk of pulmonary malignancy (p < .001 and p = .008, respectively). CONCLUSION: Locoregional failure and smoking persistence are predictors of pulmonary malignancy in patients with HNSCC.
BACKGROUND: As the locoregional control rates in head and neck squamous cell carcinoma (HNSCC) have increased, these patients may suffer distant metastasis in a higher proportion of cases. Clinicopathological characteristics allowing prediction of high-risk profile would allow adapting posttreatment surveillance to individual risk. METHODS: A retrospective review of all patients with HNSCC treated at the Jewish General Hospital, McGill University, Montreal, Quebec, Canada, between 1999 and 2008 was conducted for this study. RESULTS: The study included 428 patients with a mean follow-up of 65 months (±SEM 1.7). Eighty patients (18.6%) developed pulmonary malignancy during follow-up. In multivariate Cox-regression analysis, locoregional failure and current smoking were associated with higher risk of pulmonary malignancy (p < .001 and p = .008, respectively). CONCLUSION: Locoregional failure and smoking persistence are predictors of pulmonary malignancy in patients with HNSCC.
Authors: Jonas Werner; Martin W Hüllner; Niels J Rupp; Alexander M Huber; Martina A Broglie; Gerhard F Huber; Grégoire B Morand Journal: Sci Rep Date: 2019-06-20 Impact factor: 4.379
Authors: Grégoire B Morand; Domenic G Vital; Ken Kudura; Jonas Werner; Sandro J Stoeckli; Gerhard F Huber; Martin W Huellner Journal: Sci Rep Date: 2018-08-07 Impact factor: 4.379