Laurence Toqué1,2, Antoine Hamy1,2, Jean-Francois Hamel2,3, Elodie Cesbron4, Pauline Hulo2, Solen Robert2, Christophe Aube1,5, Emilie Lermite1,2, Aurélien Venara1,2. 1. Visceral and Endocrinal Surgery Department, University Hospital of Angers, Angers, France. 2. LUNAM, University of Angers, France. 3. Department of Biostatistics and Methodology, University Hospital of Angers, France. 4. Department of Hepato-gastroenterology, University Hospital of Angers, France. 5. Department of Medical Imaging, University of Angers, Angers, France.
Abstract
OBJECTIVE: Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this single-center, retrospective cohort study was to investigate the incidence of SVT and to determine the connected risk factors. METHODS: All consecutive patients with acute pancreatitis (AP) managed in our hospital were included. The primary outcome was the occurrence of SVT and data was collected in accordance with Ranson's criteria. RESULTS: A total of 318 patients were included, of whom 124 (39.0%) were women. Biliary lithiasis was the main cause of pancreatitis (n = 156, 49.1%). A total of 19 (6.0%) SVT were identified. In univariate analysis, alcohol intake, smoking and male gender were associated with SVT (P = 0.005, 0.003 and 0.007, respectively). Biological parameters significantly associated with thrombosis were lactate dehydrogenase (LDH) < 500 U/L and hyperglycemia (≥ 10 mmol/L) (P = 0.009 and 0.016, respectively). In multivariate analysis, prothrombin time >75% was a protective factor against thrombosis (OR 0.148, P = 0.019). Leukocytes >10 × 10(9)/L (OR 6.397, P = 0.034), hyperglycemia (≥ 10 mmol/L) (OR 6.845, P = 0.023), LDH < 500 U/L ((OR 22.61, P = 0.001) and alcoholic etiology (OR 8.960, P = 0.041) were risk factors for SVT. CONCLUSIONS: Alcohol intake, male gender and smoking should focus the physician's attention on the risk of SVT. When further associated with certain biological parameters, the physicians should consider therapeutic anticoagulation to prevent SVT.
OBJECTIVE:Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this single-center, retrospective cohort study was to investigate the incidence of SVT and to determine the connected risk factors. METHODS: All consecutive patients with acute pancreatitis (AP) managed in our hospital were included. The primary outcome was the occurrence of SVT and data was collected in accordance with Ranson's criteria. RESULTS: A total of 318 patients were included, of whom 124 (39.0%) were women. Biliary lithiasis was the main cause of pancreatitis (n = 156, 49.1%). A total of 19 (6.0%) SVT were identified. In univariate analysis, alcohol intake, smoking and male gender were associated with SVT (P = 0.005, 0.003 and 0.007, respectively). Biological parameters significantly associated with thrombosis were lactate dehydrogenase (LDH) < 500 U/L and hyperglycemia (≥ 10 mmol/L) (P = 0.009 and 0.016, respectively). In multivariate analysis, prothrombin time >75% was a protective factor against thrombosis (OR 0.148, P = 0.019). Leukocytes >10 × 10(9)/L (OR 6.397, P = 0.034), hyperglycemia (≥ 10 mmol/L) (OR 6.845, P = 0.023), LDH < 500 U/L ((OR 22.61, P = 0.001) and alcoholic etiology (OR 8.960, P = 0.041) were risk factors for SVT. CONCLUSIONS:Alcohol intake, male gender and smoking should focus the physician's attention on the risk of SVT. When further associated with certain biological parameters, the physicians should consider therapeutic anticoagulation to prevent SVT.
Authors: Danilo Pagliari; Rossella Cianci; Maria Gabriella Brizi; Francesco Antonio Mancarella; Massimiliano Musso; Marco Cintoni; Laura Franza; Roberto Antonio Flore; Antonio Gasbarrini; Paolo Tondi Journal: Intern Emerg Med Date: 2020-01-08 Impact factor: 3.397
Authors: Paulina Dumnicka; Beata Kuśnierz-Cabala; Mateusz Sporek; Małgorzata Mazur-Laskowska; Krzysztof Gil; Marek Kuźniewski; Piotr Ceranowicz; Zygmunt Warzecha; Artur Dembiński; Joanna Bonior; Ryszard Drożdż Journal: Int J Mol Sci Date: 2017-04-02 Impact factor: 5.923
Authors: Saurabh Chandan; Avanija Buddam; Shahab R Khan; Babu P Mohan; Daryl Ramai; Mohammad Bilal; Banreet Dhindsa; Neil Bhogal; Lena L Kassab; Hemant Goyal; Abhilash Perisetti; Antonio Facciorusso; Douglas G Adler Journal: Ann Gastroenterol Date: 2021-09-14