| Literature DB >> 26512762 |
Taylor B Turner1, Warner K Huh1.
Abstract
Currently available human papillomavirus (HPV) vaccines are very successful at preventing persistent HPV infection and premalignant cervical lesions. In part due to the unique aspects of HPV immunogenicity and high levels of efficacy no immune correlate has been identified for HPV vaccination. Serum neutralizing antibodies are used to measure vaccine response, but their role as a correlate has not been verified, and this theory fails to explain the prevention of HPV related non-mucosal lesions. Identifying a true correlate would aid in future work in this area but will be difficult in the setting of a highly efficacious vaccine.Entities:
Keywords: Human papilloma virus vaccine; immune correlate
Mesh:
Substances:
Year: 2015 PMID: 26512762 PMCID: PMC4964637 DOI: 10.1080/21645515.2015.1103936
Source DB: PubMed Journal: Hum Vaccin Immunother ISSN: 2164-5515 Impact factor: 3.452