Literature DB >> 26512274

Primary Spinal Cord Oligodendroglioma with Postoperative Adjuvant Radiotherapy: A Case Report.

Woon Tak Yuh1, Chun Kee Chung1, Sung-Hye Park2.   

Abstract

Primary spinal cord oligodendrogliomas are rare tumors comprising two percent of all spinal cord tumors. Although a treatment guideline has yet to be established, maximal surgical resection is primary in the treatment of spinal cord oligodendrogliomas. Adjuvant radiotherapy has remained controversial, and it is unclear whether chemotherapy adds any benefit. In this case report, the authors present a 24-year-old male who had a seven-year history of left leg weakness and a radiating pain in both legs. Magnetic resonance image (MRI) showed an intramedullary mass at the T4-T8 level. He underwent subtotal removal of the tumor and pathologic diagnosis revealed a WHO grade II oligodendroglioma. The patient was treated with radiotherapy postoperatively and followed up with MRI annually. Clinical and radiological status of the patient had been stationary for four years after the surgery. The five-year follow-up MRI showed an increase in the size and extent of the residual tumor. Despite radiological progression, considering that symptoms and the performance status of the patient had remained unchanged, further treatment has not been performed. Given the clinical outcome of this patient, close observation after subtotal removal with adjuvant radiotherapy is one of the acceptable treatment options for WHO grade II spinal cord oligodendrogliomas.

Entities:  

Keywords:  Chromosome 1p/19q co-deletion; MGMT gene promoter methylation; Oligodendroglioma; Radiotherapy; Spinal cord neoplasm

Year:  2015        PMID: 26512274      PMCID: PMC4623174          DOI: 10.14245/kjs.2015.12.3.160

Source DB:  PubMed          Journal:  Korean J Spine        ISSN: 1738-2262


  10 in total

1.  Spinal oligodendroglioma with gliomatosis in a child. Case report.

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Journal:  J Neurosurg       Date:  2000-01       Impact factor: 5.115

2.  Prospective randomized trial of low- versus high-dose radiation therapy in adults with supratentorial low-grade glioma: initial report of a North Central Cancer Treatment Group/Radiation Therapy Oncology Group/Eastern Cooperative Oncology Group study.

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Journal:  J Clin Oncol       Date:  2002-05-01       Impact factor: 44.544

3.  Spinal cord anaplastic oligodendroglioma with 1p deletion: report of a relapsing case treated with temozolomide.

Authors:  Fulin Wang; Guangyu Qiao; Xin Lou
Journal:  J Neurooncol       Date:  2010-12-29       Impact factor: 4.130

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Journal:  Eur J Neurol       Date:  2007-05       Impact factor: 6.089

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Journal:  Childs Nerv Syst       Date:  1998-12       Impact factor: 1.475

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Journal:  Childs Nerv Syst       Date:  2004-05-12       Impact factor: 1.475

7.  Neurosurgical treatment of oligodendroglial tumors in children and adolescents: a single-institution series of 35 consecutive patients.

Authors:  Tryggve Lundar; Bernt Johan Due-Tønnessen; Arild Egge; David Scheie; Einar Stensvold; Petter Brandal
Journal:  J Neurosurg Pediatr       Date:  2013-07-19       Impact factor: 2.375

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Journal:  Radiol Clin North Am       Date:  1988-09       Impact factor: 2.303

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Journal:  Acta Neurochir (Wien)       Date:  1980       Impact factor: 2.216

10.  Spinal cord oligodendroglioma with 1p and 19q deletions presenting with cerebral oligodendrogliomatosis.

Authors:  Kern H Guppy; Paul T Akins; Gregory S Moes; Michael D Prados
Journal:  J Neurosurg Spine       Date:  2009-06
  10 in total
  1 in total

1.  A very rare spinal cord tumor primary spinal oligodendroglioma: A review of sixty cases in the literature.

Authors:  Askin Esen Hasturk; Emre Cemal Gokce; Cagri Elbir; Gulce Gel; Suat Canbay
Journal:  J Craniovertebr Junction Spine       Date:  2017 Jul-Sep
  1 in total

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