S J van Erp1, L K Brakenhoff1, F A van Gaalen2, R van den Berg2, H H Fidder3, H W Verspaget1, T W Huizinga2, R A Veenendaal1, R Wolterbeek4, D van der Heijde2, A E van der Meulen-de Jong5, D W Hommes6. 1. Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands. 2. Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. 3. Department of Gastroenterology and Hepatology , University Medical Center Utrecht, Utrecht, The Netherlands. 4. Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands. 5. Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands ae.meulen@lumc.nl. 6. Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands Center for Inflammatory Bowel Diseases, University of California Los Angeles, Los Angeles, CA, USA.
Abstract
BACKGROUND AND AIMS: Peripheral joint complaints [pJTC] and chronic back pain [CBP] are the most common extra-intestinal manifestations in patients with inflammatory bowel disease [IBD]. This prospective study evaluates variables associated with joint/back pain, including IBD disease activity. METHODS: IBD patients with back pain ≥ 3 months and/or peripheral joint pain/swelling [n = 155], and IBD patients without joint complaints [n = 100; controls], were followed for a period of 1 year. Patients were classified as having SpondyloArthritis [SpA] according to several sets of criteria. Statistical analysis included logistic regression models and linear mixed model analysis. RESULTS: Of the 155 patients with joint/back pain, 13 had chronic back pain, 80 peripheral joint complaints, and 62 axial and peripheral joint complaints. Smoking, female gender, and IBD disease activity were independently associated with IBD joint/back pain. The Assessment in Spondyloarthritis International Society criteria for axial and peripheral SpA were fulfilled in 12.3% of patients, with 9.7% [n = 15] receiving a rheumatological diagnosis of arthritis. During the 12-month follow-up, the majority of the patients reporting joint/back pain remained stable. CONCLUSIONS: In our cohort, the majority of IBD patients reported joint/back pain and SpA was relatively common. To facilitate effective care, gastroenterologists should be aware of the various features of SpA to classify joint complaints and, by making use of an efficient referral algorithm, to refer CBP patients to the rheumatologist.
BACKGROUND AND AIMS: Peripheral joint complaints [pJTC] and chronic back pain [CBP] are the most common extra-intestinal manifestations in patients with inflammatory bowel disease [IBD]. This prospective study evaluates variables associated with joint/back pain, including IBD disease activity. METHODS: IBD patients with back pain ≥ 3 months and/or peripheral joint pain/swelling [n = 155], and IBD patients without joint complaints [n = 100; controls], were followed for a period of 1 year. Patients were classified as having SpondyloArthritis [SpA] according to several sets of criteria. Statistical analysis included logistic regression models and linear mixed model analysis. RESULTS: Of the 155 patients with joint/back pain, 13 had chronic back pain, 80 peripheral joint complaints, and 62 axial and peripheral joint complaints. Smoking, female gender, and IBD disease activity were independently associated with IBD joint/back pain. The Assessment in Spondyloarthritis International Society criteria for axial and peripheral SpA were fulfilled in 12.3% of patients, with 9.7% [n = 15] receiving a rheumatological diagnosis of arthritis. During the 12-month follow-up, the majority of the patients reporting joint/back pain remained stable. CONCLUSIONS: In our cohort, the majority of IBD patients reported joint/back pain and SpA was relatively common. To facilitate effective care, gastroenterologists should be aware of the various features of SpA to classify joint complaints and, by making use of an efficient referral algorithm, to refer CBPpatients to the rheumatologist.
Authors: S J H van Erp; L K M P Brakenhoff; M Vollmann; D van der Heijde; R A Veenendaal; H H Fidder; D W Hommes; A A Kaptein; Andrea E van der Meulen-de Jong; M Scharloo Journal: Int J Behav Med Date: 2017-04
Authors: Aimee Hiller; Luc Biedermann; Nicolas Fournier; Matthias Butter; Stephan R Vavricka; Adrian Ciurea; Gerhard Rogler; Michael Scharl Journal: PLoS One Date: 2019-04-30 Impact factor: 3.240
Authors: Jonas Zeitz; Melike Ak; Séverine Müller-Mottet; Sylvie Scharl; Luc Biedermann; Nicolas Fournier; Pascal Frei; Valerie Pittet; Michael Scharl; Michael Fried; Gerhard Rogler; Stephan Vavricka Journal: PLoS One Date: 2016-06-22 Impact factor: 3.240