R Jeanne Ruiz1, Susan Gennaro2, Caitlin O'Connor2, Alok Dwivedi3, Anne Gibeau4, Tayra Keshinover5, Tia Welsh6. 1. Texas A&M University Health Science Center College of Nursing, Bryan, TX, USA roberta.ruiz@tamhsc.edu. 2. William F. Connell School of Nursing, Boston College, New York, NY, USA. 3. Texas A&M University Health Science Center College of Nursing, Bryan, TX, USA. 4. Jacobi Medical Center, Bronx, NY, USA. 5. Columbia University Medical Center, New York, NY, USA. 6. Lincoln Medical and Mental Health Center, Bronx, NY, USA.
Abstract
OBJECTIVE: To determine the predictive capability of corticotropin-releasing hormone (CRH) as a biomarker of preterm birth (PTB) in minority women. STUDY DESIGN: Venous blood samples were obtained at 22-24 weeks' gestation in a prospective, descriptive study of 707 minority women experiencing low-risk pregnancies. CRH was analyzed using a radioimmunoassay and methanol extraction protocol. RESULT: CRH predicted PTB in both African American and Hispanic women. The odds ratio was 1.8 times greater for having a PTB if the CRH level was >24 pg/ml. The median CRH for African American women having a PTB was 46.6 pg/ml and for Hispanic women was 35.03 pg/ml. Using a receiver-operating characteristic curve, the threshold for CRH among the African American women was 30.6 pg/ml and among the Hispanic women was 27.4 pg/ml. CONCLUSION: CRH may be an important biomarker for predicting PTB in minority women, especially when combined with other predictors.
OBJECTIVE: To determine the predictive capability of corticotropin-releasing hormone (CRH) as a biomarker of preterm birth (PTB) in minority women. STUDY DESIGN: Venous blood samples were obtained at 22-24 weeks' gestation in a prospective, descriptive study of 707 minority women experiencing low-risk pregnancies. CRH was analyzed using a radioimmunoassay and methanol extraction protocol. RESULT: CRH predicted PTB in both African American and Hispanic women. The odds ratio was 1.8 times greater for having a PTB if the CRH level was >24 pg/ml. The median CRH for African American women having a PTB was 46.6 pg/ml and for Hispanic women was 35.03 pg/ml. Using a receiver-operating characteristic curve, the threshold for CRH among the African American women was 30.6 pg/ml and among the Hispanic women was 27.4 pg/ml. CONCLUSION:CRH may be an important biomarker for predicting PTB in minority women, especially when combined with other predictors.
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