Literature DB >> 2651151

Pyruvate decarboxylase is like acetolactate synthase (ILV2) and not like the pyruvate dehydrogenase E1 subunit.

J B Green1.   

Abstract

Protein sequences of pyruvate decarboxylase (PDC) derived from cloned yeast (Saccharomyces cerevisiae) and bacterial (Zymomonas mobilis) genes were compared with each other and with sequence databases. Extensive sequence similarities were found between them and with two others: cytochrome-linked pyruvate oxidase from Escherichia coli and acetolactate synthase (ilvI in E. coli; ILV2 gene in S. cerevisiae). All catalyse decarboxylation of pyruvate using thiamine pyrophosphate (TPP) as cofactor. General overall similarity suggests common ancestry for these enzymes. None of the sequences was similar to the E1 component of pyruvate dehydrogenase from E. coli which also decarboxylates pyruvate with the help of TPP.

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Year:  1989        PMID： 2651151     DOI： 10.1016/0014-5793(89)80241-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Cloning and characterization of a locus encoding an indolepyruvate decarboxylase involved in indole-3-acetic acid synthesis in Erwinia herbicola.

Authors:  M T Brandl; S E Lindow
Journal:  Appl Environ Microbiol       Date:  1996-11       Impact factor: 4.792

2.  pdc1(0) mutants of Saccharomyces cerevisiae give evidence for an additional structural PDC gene: cloning of PDC5, a gene homologous to PDC1.

Authors:  P G Seeboth; K Bohnsack; C P Hollenberg
Journal:  J Bacteriol       Date:  1990-02       Impact factor: 3.490

3.  The carboligation reaction of acetohydroxyacid synthase II: steady-state intermediate distributions in wild type and mutants by NMR.

Authors:  Kai Tittmann; Maria Vyazmensky; Gerhard Hübner; Ze'ev Barak; David M Chipman
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-07       Impact factor: 11.205

4.  Evolutionary analysis of the TPP-dependent enzyme family.

Authors:  Seán J Costelloe; John M Ward; Paul A Dalby
Journal:  J Mol Evol       Date:  2007-11-28       Impact factor: 2.395

5.  Characterization of PDC6, a third structural gene for pyruvate decarboxylase in Saccharomyces cerevisiae.

Authors:  S Hohmann
Journal:  J Bacteriol       Date:  1991-12       Impact factor: 3.490

6.  Expressed sequence tag analysis of khat (Catha edulis) provides a putative molecular biochemical basis for the biosynthesis of phenylpropylamino alkaloids.

Authors:  Jillian M Hagel; Raz Krizevski; Korey Kilpatrick; Yaron Sitrit; Frédéric Marsolais; Efraim Lewinsohn; Peter J Facchini
Journal:  Genet Mol Biol       Date:  2011-10-01       Impact factor: 1.771

7.  Pyruvate decarboxylase activity of the acetohydroxyacid synthase of Thermotoga maritima.

Authors:  Mohammad S Eram; Kesen Ma
Journal:  Biochem Biophys Rep       Date:  2016-07-16

8.  A standard numbering scheme for thiamine diphosphate-dependent decarboxylases.

Authors:  Constantin Vogel; Michael Widmann; Martina Pohl; Jürgen Pleiss
Journal:  BMC Biochem       Date:  2012-11-17       Impact factor: 4.059
  8 in total

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