| Literature DB >> 26511166 |
Biao Zeng1,2, Guang-Da Liu1, Bao-Bao Zhang1, Shan-shan Wang1, Rui Ma1, Bei-Shan Zhong1, Bai-qiu He1, Yan Liang3, Fei-Hua Wu1.
Abstract
A new triterpene saponin, 3β,16β,23α,28β,30β-pentahydroxyl-olean-11,13(18)-dien-3β-yl-[β-D-glucopyranosyl-(1→2)]-[β-D-glucopyranosyl-(1→3)]-β-D-fucopyranoside, was named Clinoposaponin D (1), together with six known triterpene saponins, buddlejasaponin IVb (2), buddlejasaponin IVa (3), buddlejasaponin IV (4), clinopodisides D (5), 11α,16β,23,28-Tetrahydroxyolean-12-en-3β-yl-[β-D-glucopyranosyl-(1→2)]-[β-D-glucopyranosyl-(1→3)]-β-D-fucopyranoside (6) and prosaikogenin A (7), and two known triterpenes, saikogenin A (8) and saikogenin F (9) were isolated from Clinopodium chinense (Benth.) O. Kuntze. Their structures were elucidated on the basis of 1D, 2D NMR and MS analysis. Meanwhile, the effects of all compounds on rabbit platelet aggregation and thrombin time (TT) were investigated in vitro. Compounds 4 and 7 had significant promoting effects on platelet aggregation with EC50 value at 53.4 and 12.2 μM, respectively. In addition, the highest concentration (200 μM) of compounds 2 and 9 shortened TT by 20.6 and 25.1%, respectively.Entities:
Keywords: Clinopodium chinense (Benth.) O. Kuntze; platelet aggregation; thrombin time; triterpene saponin
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Year: 2015 PMID： 26511166 DOI： 10.1080/14786419.2015.1095745
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861