Literature DB >> 26510858

Patients with a High Polygenic Risk of Breast Cancer do not have An Increased Risk of Radiotherapy Toxicity.

Leila Dorling1, Gillian C Barnett2, Kyriaki Michailidou3, Charlotte E Coles2, Neil G Burnet4, John Yarnold5, Rebecca M Elliott6, Alison M Dunning7, Paul D P Pharoah7, Catharine M West6.   

Abstract

PURPOSE: It has been hypothesized that increased predisposition to breast cancer may correlate with radiosensitivity, and thus increased risk of toxicity following breast irradiation. This study investigated the relationship between common breast cancer risk variants and radiotherapy toxicity. EXPERIMENTAL
DESIGN: SNP genotypes were determined in female breast cancer patients from the RAPPER (Radiogenomics: Assessment of polymorphisms for predicting the effects of radiotherapy) study using the Illumina CytoSNP12 genome-wide array. A further 15,582,449 genotypes were imputed using the 1000 Genomes Project reference panel. Patient (n = 1,160) polygenic risk scores were generated by summing risk-allele dosages, both unweighted and weighted by published effect sizes for breast cancer risk. Regression models were used to test associations of individual variants and polygenic risk scores with acute and late toxicity phenotypes (telangiectasia, breast edema, photographically assessed shrinkage, induration, pigmentation, breast pain, breast sensitivity, and overall toxicity).
RESULTS: Genotypes of 90 confirmed breast cancer risk variants were accurately determined and polygenic risk scores were approximately normally distributed. Variant rs6964587 was associated with increased breast edema 5 years following radiotherapy (Beta, 0.22; 95% confidence interval, 0.09-0.34; P = 7 × 10(-4)). No other associations were found between individual variants or the unweighted (P > 0.17) or weighted (P > 0.13) polygenic risk score and radiotherapy toxicity. This study had >87% power to detect an association between the polygenic risk score (relative risk > 1.1) and toxicity.
CONCLUSIONS: Cancer patients with a high polygenic predisposition to breast cancer do not have an increased risk of radiotherapy toxicity up to 5 years following radiotherapy but individual variants may increase risk. ©2015 American Association for Cancer Research.

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Mesh：

Year:  2015        PMID： 26510858      PMCID： PMC4751620          DOI： 10.1158/1078-0432.CCR-15-1080

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  23 in total

1.  A linear complexity phasing method for thousands of genomes.

Authors:  Olivier Delaneau; Jonathan Marchini; Jean-François Zagury
Journal:  Nat Methods       Date:  2011-12-04       Impact factor: 28.547

2.  Patient-to-Patient Variability in the Expression of Radiation-Induced Normal Tissue Injury.

Authors: 
Journal:  Semin Radiat Oncol       Date:  1994-04       Impact factor: 5.934

3.  Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer.

Authors:  Ulrike Hoeller; Kerstin Borgmann; Michael Bonacker; Antje Kuhlmey; Amira Bajrovic; Horst Jung; Winfried Alberti; Ekkehard Dikomey
Journal:  Radiother Oncol       Date:  2003-11       Impact factor: 6.280

Review 4.  Chromosomal radiosensitivity and low penetrance predisposition to cancer.

Authors:  D Scott
Journal:  Cytogenet Genome Res       Date:  2004       Impact factor: 1.636

5.  Standardized Total Average Toxicity score: a scale- and grade-independent measure of late radiotherapy toxicity to facilitate pooling of data from different studies.

Authors:  Gillian C Barnett; Catharine M L West; Charlotte E Coles; Paul D P Pharoah; Christopher J Talbot; Rebecca M Elliott; George A Tanteles; R Paul Symonds; Jennifer S Wilkinson; Alison M Dunning; Neil G Burnet; Søren M Bentzen
Journal:  Int J Radiat Oncol Biol Phys       Date:  2011-05-24       Impact factor: 7.038

6.  Radiosensitivity, radiogenomics and RAPPER.

Authors:  N G Burnet; R M Elliott; A Dunning; C M L West
Journal:  Clin Oncol (R Coll Radiol)       Date:  2006-09       Impact factor: 4.126

7.  Genotype imputation with thousands of genomes.

Authors:  Bryan Howie; Jonathan Marchini; Matthew Stephens
Journal:  G3 (Bethesda)       Date:  2011-11-01       Impact factor: 3.154

8.  Prediction of breast cancer risk based on profiling with common genetic variants.

Authors:  Nasim Mavaddat; Paul D P Pharoah; Kyriaki Michailidou; Jonathan Tyrer; Mark N Brook; Manjeet K Bolla; Qin Wang; Joe Dennis; Alison M Dunning; Mitul Shah; Robert Luben; Judith Brown; Stig E Bojesen; Børge G Nordestgaard; Sune F Nielsen; Henrik Flyger; Kamila Czene; Hatef Darabi; Mikael Eriksson; Julian Peto; Isabel Dos-Santos-Silva; Frank Dudbridge; Nichola Johnson; Marjanka K Schmidt; Annegien Broeks; Senno Verhoef; Emiel J Rutgers; Anthony Swerdlow; Alan Ashworth; Nick Orr; Minouk J Schoemaker; Jonine Figueroa; Stephen J Chanock; Louise Brinton; Jolanta Lissowska; Fergus J Couch; Janet E Olson; Celine Vachon; Vernon S Pankratz; Diether Lambrechts; Hans Wildiers; Chantal Van Ongeval; Erik van Limbergen; Vessela Kristensen; Grethe Grenaker Alnæs; Silje Nord; Anne-Lise Borresen-Dale; Heli Nevanlinna; Taru A Muranen; Kristiina Aittomäki; Carl Blomqvist; Jenny Chang-Claude; Anja Rudolph; Petra Seibold; Dieter Flesch-Janys; Peter A Fasching; Lothar Haeberle; Arif B Ekici; Matthias W Beckmann; Barbara Burwinkel; Frederik Marme; Andreas Schneeweiss; Christof Sohn; Amy Trentham-Dietz; Polly Newcomb; Linda Titus; Kathleen M Egan; David J Hunter; Sara Lindstrom; Rulla M Tamimi; Peter Kraft; Nazneen Rahman; Clare Turnbull; Anthony Renwick; Sheila Seal; Jingmei Li; Jianjun Liu; Keith Humphreys; Javier Benitez; M Pilar Zamora; Jose Ignacio Arias Perez; Primitiva Menéndez; Anna Jakubowska; Jan Lubinski; Katarzyna Jaworska-Bieniek; Katarzyna Durda; Natalia V Bogdanova; Natalia N Antonenkova; Thilo Dörk; Hoda Anton-Culver; Susan L Neuhausen; Argyrios Ziogas; Leslie Bernstein; Peter Devilee; Robert A E M Tollenaar; Caroline Seynaeve; Christi J van Asperen; Angela Cox; Simon S Cross; Malcolm W R Reed; Elza Khusnutdinova; Marina Bermisheva; Darya Prokofyeva; Zalina Takhirova; Alfons Meindl; Rita K Schmutzler; Christian Sutter; Rongxi Yang; Peter Schürmann; Michael Bremer; Hans Christiansen; Tjoung-Won Park-Simon; Peter Hillemanns; Pascal Guénel; Thérèse Truong; Florence Menegaux; Marie Sanchez; Paolo Radice; Paolo Peterlongo; Siranoush Manoukian; Valeria Pensotti; John L Hopper; Helen Tsimiklis; Carmel Apicella; Melissa C Southey; Hiltrud Brauch; Thomas Brüning; Yon-Dschun Ko; Alice J Sigurdson; Michele M Doody; Ute Hamann; Diana Torres; Hans-Ulrich Ulmer; Asta Försti; Elinor J Sawyer; Ian Tomlinson; Michael J Kerin; Nicola Miller; Irene L Andrulis; Julia A Knight; Gord Glendon; Anna Marie Mulligan; Georgia Chenevix-Trench; Rosemary Balleine; Graham G Giles; Roger L Milne; Catriona McLean; Annika Lindblom; Sara Margolin; Christopher A Haiman; Brian E Henderson; Fredrick Schumacher; Loic Le Marchand; Ursula Eilber; Shan Wang-Gohrke; Maartje J Hooning; Antoinette Hollestelle; Ans M W van den Ouweland; Linetta B Koppert; Jane Carpenter; Christine Clarke; Rodney Scott; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Hermann Brenner; Volker Arndt; Christa Stegmaier; Aida Karina Dieffenbach; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Mervi Grip; Kenneth Offit; Joseph Vijai; Mark Robson; Rohini Rau-Murthy; Miriam Dwek; Ruth Swann; Katherine Annie Perkins; Mark S Goldberg; France Labrèche; Martine Dumont; Diana M Eccles; William J Tapper; Sajjad Rafiq; Esther M John; Alice S Whittemore; Susan Slager; Drakoulis Yannoukakos; Amanda E Toland; Song Yao; Wei Zheng; Sandra L Halverson; Anna González-Neira; Guillermo Pita; M Rosario Alonso; Nuria Álvarez; Daniel Herrero; Daniel C Tessier; Daniel Vincent; Francois Bacot; Craig Luccarini; Caroline Baynes; Shahana Ahmed; Mel Maranian; Catherine S Healey; Jacques Simard; Per Hall; Douglas F Easton; Montserrat Garcia-Closas
Journal:  J Natl Cancer Inst       Date:  2015-04-08       Impact factor: 13.506

9.  STROGAR - STrengthening the Reporting Of Genetic Association studies in Radiogenomics.

Authors:  Sarah L Kerns; Dirk de Ruysscher; Christian N Andreassen; David Azria; Gillian C Barnett; Jenny Chang-Claude; Susan Davidson; Joseph O Deasy; Alison M Dunning; Harry Ostrer; Barry S Rosenstein; Catharine M L West; Søren M Bentzen
Journal:  Radiother Oncol       Date:  2013-08-27       Impact factor: 6.280

10.  An integrated map of genetic variation from 1,092 human genomes.

Authors:  Goncalo R Abecasis; Adam Auton; Lisa D Brooks; Mark A DePristo; Richard M Durbin; Robert E Handsaker; Hyun Min Kang; Gabor T Marth; Gil A McVean
Journal:  Nature       Date:  2012-11-01       Impact factor: 49.962
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  5 in total

1.  Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis.

Authors:  Christoph Weigel; Marlon R Veldwijk; Christopher C Oakes; Petra Seibold; Alla Slynko; David B Liesenfeld; Mariona Rabionet; Sabrina A Hanke; Frederik Wenz; Elena Sperk; Axel Benner; Christoph Rösli; Roger Sandhoff; Yassen Assenov; Christoph Plass; Carsten Herskind; Jenny Chang-Claude; Peter Schmezer; Odilia Popanda
Journal:  Nat Commun       Date:  2016-03-11       Impact factor: 14.919

Review 2.  Data-Based Radiation Oncology: Design of Clinical Trials in the Toxicity Biomarkers Era.

Authors:  David Azria; Ariane Lapierre; Sophie Gourgou; Dirk De Ruysscher; Jacques Colinge; Philippe Lambin; Muriel Brengues; Tim Ward; Søren M Bentzen; Hubert Thierens; Tiziana Rancati; Christopher J Talbot; Ana Vega; Sarah L Kerns; Christian Nicolaj Andreassen; Jenny Chang-Claude; Catharine M L West; Corey M Gill; Barry S Rosenstein
Journal:  Front Oncol       Date:  2017-04-27       Impact factor: 6.244

3.  Assessment of the prognostic role of a 94-single nucleotide polymorphisms risk score in early breast cancer in the SIGNAL/PHARE prospective cohort: no correlation with clinico-pathological characteristics and outcomes.

Authors:  Elsa Curtit; Xavier Pivot; Julie Henriques; Sophie Paget-Bailly; Pierre Fumoleau; Maria Rios; Hervé Bonnefoi; Thomas Bachelot; Patrick Soulié; Christelle Jouannaud; Hugues Bourgeois; Thierry Petit; Isabelle Tennevet; David Assouline; Marie-Christine Mathieu; Jean-Philippe Jacquin; Sandrine Lavau-Denes; Ariane Darut-Jouve; Jean-Marc Ferrero; Carole Tarpin; Christelle Lévy; Valérie Delecroix; Véronique Trillet-Lenoir; Oana Cojocarasu; Jérôme Meunier; Jean-Yves Pierga; Pierre Kerbrat; Céline Faure-Mercier; Hélène Blanché; Mourad Sahbatou; Anne Boland; Delphine Bacq; Céline Besse; Gilles Thomas; Jean-François Deleuze; Iris Pauporté; Gilles Romieu; David G Cox
Journal:  Breast Cancer Res       Date:  2017-08-22       Impact factor: 6.466

Review 4.  Improving radiotherapy in cancer treatment: Promises and challenges.

Authors:  Helen H W Chen; Macus Tien Kuo
Journal:  Oncotarget       Date:  2017-06-08

5.  A six-gene-based signature for breast cancer radiotherapy sensitivity estimation.

Authors:  Xing Chen; Junjie Zheng; Min Ling Zhuo; Ailong Zhang; Zhenhui You
Journal:  Biosci Rep       Date:  2020-12-23       Impact factor: 3.840
  5 in total

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