| Literature DB >> 26509484 |
Christopher R Martens1, Danielle L Kirkman, David G Edwards.
Abstract
Endothelial dysfunction occurs in chronic kidney disease (CKD) and increases the risk for cardiovascular disease. The mechanisms of endothelial dysfunction seem to evolve throughout kidney disease progression, culminating in reduced L-arginine transport and impaired nitric oxide bioavailability in advanced disease. This review examines the hypothesis that aerobic exercise may reverse endothelial dysfunction by improving endothelial cell L-arginine uptake in CKD.Entities:
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Year: 2016 PMID: 26509484 PMCID: PMC5650477 DOI: 10.1249/JES.0000000000000065
Source DB: PubMed Journal: Exerc Sport Sci Rev ISSN: 0091-6331 Impact factor: 6.230