Literature DB >> 26509451

Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials.

Fabián Rueda1,2,3, María Virtudes Céspedes3,4, Oscar Conchillo-Solé1, Alejandro Sánchez-Chardi5, Joaquin Seras-Franzoso1,2,3, Rafael Cubarsi6, Alberto Gallardo3,4, Mireia Pesarrodona1,2,3, Neus Ferrer-Miralles1,2,3, Xavier Daura1,7, Esther Vázquez1,2,3, Elena García-Fruitós1,2,3, Ramón Mangues3,4, Ugutz Unzueta3,4, Antonio Villaverde1,2,3.   

Abstract

The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords:  biodistribution; biofabrication; cell quality control; nanoparticles; protein materials

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Substances：

Year:  2015        PMID： 26509451     DOI： 10.1002/adma.201503676

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  9 in total

1.  Self-Assembled Nanobodies as Selectively Targeted, Nanostructured, and Multivalent Materials.

Authors:  Laura Sánchez-García; Eric Voltà-Durán; Eloi Parladé; Elisa Mazzega; Alejandro Sánchez-Chardi; Naroa Serna; Hèctor López-Laguna; Mara Mitstorfer; Ugutz Unzueta; Esther Vázquez; Antonio Villaverde; Ario de Marco
Journal:  ACS Appl Mater Interfaces       Date:  2021-06-15       Impact factor: 10.383

2.  GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases.

Authors:  Rita Sala; Elisa Rioja-Blanco; Naroa Serna; Laura Sánchez-García; Patricia Álamo; Lorena Alba-Castellón; Isolda Casanova; Antonio López-Pousa; Ugutz Unzueta; María Virtudes Céspedes; Esther Vázquez; Antonio Villaverde; Ramon Mangues
Journal:  Drug Deliv       Date:  2022-12       Impact factor: 6.819

3.  Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.

Authors:  Fabián Rueda; María Virtudes Céspedes; Alejandro Sánchez-Chardi; Joaquin Seras-Franzoso; Mireia Pesarrodona; Neus Ferrer-Miralles; Esther Vázquez; Ursula Rinas; Ugutz Unzueta; Uwe Mamat; Ramón Mangues; Elena García-Fruitós; Antonio Villaverde
Journal:  Microb Cell Fact       Date:  2016-04-08       Impact factor: 5.328

4.  Functional inclusion bodies produced in the yeast Pichia pastoris.

Authors:  Fabián Rueda; Brigitte Gasser; Alejandro Sánchez-Chardi; Mònica Roldán; Sandra Villegas; Verena Puxbaum; Neus Ferrer-Miralles; Ugutz Unzueta; Esther Vázquez; Elena Garcia-Fruitós; Diethard Mattanovich; Antonio Villaverde
Journal:  Microb Cell Fact       Date:  2016-10-01       Impact factor: 5.328

5.  Selective depletion of metastatic stem cells as therapy for human colorectal cancer.

Authors:  María Virtudes Céspedes; Ugutz Unzueta; Anna Aviñó; Alberto Gallardo; Patricia Álamo; Rita Sala; Alejandro Sánchez-Chardi; Isolda Casanova; María Antònia Mangues; Antonio Lopez-Pousa; Ramón Eritja; Antonio Villaverde; Esther Vázquez; Ramón Mangues
Journal:  EMBO Mol Med       Date:  2018-10       Impact factor: 12.137

6.  Ion-dependent slow protein release from in vivo disintegrating micro-granules.

Authors:  Patricia Álamo; Eloi Parladé; Hèctor López-Laguna; Eric Voltà-Durán; Ugutz Unzueta; Esther Vazquez; Ramon Mangues; Antonio Villaverde
Journal:  Drug Deliv       Date:  2021-12       Impact factor: 6.419

7.  Artificial Inclusion Bodies for Clinical Development.

Authors:  Julieta M Sánchez; Hèctor López-Laguna; Patricia Álamo; Naroa Serna; Alejandro Sánchez-Chardi; Verónica Nolan; Olivia Cano-Garrido; Isolda Casanova; Ugutz Unzueta; Esther Vazquez; Ramon Mangues; Antonio Villaverde
Journal:  Adv Sci (Weinh)       Date:  2019-11-27       Impact factor: 16.806

8.  Time-Prolonged Release of Tumor-Targeted Protein-MMAE Nanoconjugates from Implantable Hybrid Materials.

Authors:  Naroa Serna; Aïda Falgàs; Annabel García-León; Ugutz Unzueta; Yáiza Núñez; Alejandro Sánchez-Chardi; Carlos Martínez-Torró; Ramón Mangues; Esther Vazquez; Isolda Casanova; Antonio Villaverde
Journal:  Pharmaceutics       Date:  2022-01-14       Impact factor: 6.321

9.  The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies.

Authors:  Julieta María Sánchez; José Vicente Carratalá; Naroa Serna; Ugutz Unzueta; Verónica Nolan; Alejandro Sánchez-Chardi; Eric Voltà-Durán; Hèctor López-Laguna; Neus Ferrer-Miralles; Antonio Villaverde; Esther Vazquez
Journal:  Pharmaceutics       Date:  2022-03-10       Impact factor: 6.321
  9 in total

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