K Seyssel1,2,3, X Allirot1,4, J-A Nazare1,2,3, H Roth1,5, E Blond1,2,6, A Charrié1,2,3,6, A Mialon6, J Drai1,2,3,6, M Laville1,2,3, E Disse1,2,3. 1. Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud, Pierre Bénite, France. 2. Centre Européen Pour la Nutrition et la Santé, Centre Hospitalier Lyon Sud, Pierre Bénite, France. 3. CarMeN-INSERM U1060-Université Claude Bernard Lyon 1, Faculté de Médecine de Maïeutique Lyon Sud, Pierre-Bénite, France. 4. Centre de Recherche de l'Institut Paul Bocuse, Château du Vivier, Ecully, France. 5. Poôe Recherche, CHU Grenoble, INSERM U1055-Bioénergétique, Université Grenoble Alpes, Grenoble, France. 6. Laboratoire de Biochimie du Centre Hospitalier Lyon Sud HCL, Pierre-Bénite, France.
Abstract
BACKGROUND/ OBJECTIVES: Plasma ghrelin secretion over time in humans is characterized by pre-prandial increases and by post-prandial decreases all day long. However, some authors who measured ghrelin concentrations around meals showed a rise in plasma ghrelin concentration after meal initiation followed by the typical post-prandial decrease. In order to confirm this observation that has never been discussed, we described ghrelin profiles around four eating episodes in the morning in adult men. SUBJECTS/ METHODS: Twenty normal-weight and 17 obese men were instructed to eat four fixed meals (706 kJ) 10 min long at 0800 h, 0900 h, 1000 h and 1100 h. Using frequent blood sampling, we determined plasma acyl-ghrelin concentrations around those eating episodes. Glucose, insulin and GLP-1 concentrations were also measured. RESULTS: The meals consumption induced a significant increase in plasma acyl-ghrelin concentrations 10 min after meal initiation (P<0.0001): +20.9±5.8 and +10.7±3.3 pg/ml in normal-weight and obese subjects for the first meal; +10.4±3.0 and +5.5±3.9 pg/ml in normal-weight and obese subjects for the second meal; +12.4±3.6 and +4.2±2.1 pg/ml in normal-weight and obese subjects for the third meal; and +4.4±4.1 and +3.3±2.61 pg/ml in normal-weight and obese subjects for the fourth meal. CONCLUSIONS: This study is the first to describe and discuss the post-meal initiation ghrelin increase. This finding is consistent in normal-weight and obese individuals.
BACKGROUND/ OBJECTIVES: Plasma ghrelin secretion over time in humans is characterized by pre-prandial increases and by post-prandial decreases all day long. However, some authors who measured ghrelin concentrations around meals showed a rise in plasma ghrelin concentration after meal initiation followed by the typical post-prandial decrease. In order to confirm this observation that has never been discussed, we described ghrelin profiles around four eating episodes in the morning in adult men. SUBJECTS/ METHODS: Twenty normal-weight and 17 obesemen were instructed to eat four fixed meals (706 kJ) 10 min long at 0800 h, 0900 h, 1000 h and 1100 h. Using frequent blood sampling, we determined plasma acyl-ghrelin concentrations around those eating episodes. Glucose, insulin and GLP-1 concentrations were also measured. RESULTS: The meals consumption induced a significant increase in plasma acyl-ghrelin concentrations 10 min after meal initiation (P<0.0001): +20.9±5.8 and +10.7±3.3 pg/ml in normal-weight and obese subjects for the first meal; +10.4±3.0 and +5.5±3.9 pg/ml in normal-weight and obese subjects for the second meal; +12.4±3.6 and +4.2±2.1 pg/ml in normal-weight and obese subjects for the third meal; and +4.4±4.1 and +3.3±2.61 pg/ml in normal-weight and obese subjects for the fourth meal. CONCLUSIONS: This study is the first to describe and discuss the post-meal initiation ghrelin increase. This finding is consistent in normal-weight and obese individuals.
Authors: Karen E Foster-Schubert; Joost Overduin; Catherine E Prudom; Jianhua Liu; Holly S Callahan; Bruce D Gaylinn; Michael O Thorner; David E Cummings Journal: J Clin Endocrinol Metab Date: 2008-01-15 Impact factor: 5.958