Literature DB >> 26508023

SATB2 suppresses gastric cancer cell proliferation and migration.

Liucheng Wu1, Jiansi Chen2, Yuzhou Qin2, Xianwei Mo2, Minwei Huang2, Haiming Ru2, Yang Yang2, Jungang Liu2, Yuan Lin2.   

Abstract

Gastric cancer is one of the death-related malignant tumors worldwide. It remains a challenge for the diagnosis and treatment of gastric cancer. Special AT-rich sequence-binding protein 2 (SATB2) is a new tumor suppressive gene and plays important roles in many cancers. However, the role of SATB2 in gastric cancer is still unknown. In the present study, we demonstrated that downregulation of SATB2 was associated with shortened survival in patients with gastric cancer. Ectopic expression of SATB2 inhibited gastric cancer cell proliferation, colony formation, and migration. Overexpression of SATB2 repressed the expression of extracellular signal-regulated kinase 5 (ERK5), and activation of ERK5 restored the SATB2-induced inhibition of proliferation and migration in gastric cancer. This study provided evidence that SATB2 acted as a tumor suppressive gene gastric cancer, serving as a potential therapeutic target.

Entities:  

Keywords:  ERK5; Gastric cancer; Proliferation; SATB2

Mesh：

Substances：

Year:  2015        PMID： 26508023     DOI： 10.1007/s13277-015-4282-5

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  38 in total

1.  MEK5-ERK5 pathway associates with poor survival of breast cancer patients after systemic treatments.

Authors:  Mariska Miranda; Esdy Rozali; Kum Kum Khanna; Fares Al-Ejeh
Journal:  Oncoscience       Date:  2015-02-20

2.  MiRNA-34a inhibits EGFR-signaling-dependent MMP7 activation in gastric cancer.

Authors:  Gang Liu; Chuanshen Jiang; Dazhou Li; Rong Wang; Wen Wang
Journal:  Tumour Biol       Date:  2014-07-01

3.  Identification of SATB2 as the cleft palate gene on 2q32-q33.

Authors:  David R FitzPatrick; Ian M Carr; Lorna McLaren; Jack P Leek; Patrick Wightman; Kathy Williamson; Philippe Gautier; Niolette McGill; Caroline Hayward; Helen Firth; Alex F Markham; Judy A Fantes; David T Bonthron
Journal:  Hum Mol Genet       Date:  2003-07-29       Impact factor: 6.150

4.  SATB2 is a novel marker of osteoblastic differentiation in bone and soft tissue tumours.

Authors:  James R Conner; Jason L Hornick
Journal:  Histopathology       Date:  2013-05-23       Impact factor: 5.087

5.  ERK5 is a critical mediator of inflammation-driven cancer.

Authors:  Katherine G Finegan; Diana Perez-Madrigal; James R Hitchin; Clare C Davies; Allan M Jordan; Cathy Tournier
Journal:  Cancer Res       Date:  2015-02-03       Impact factor: 12.701

6.  Diagnostic value of circulating microRNAs for gastric cancer in Asian populations: a meta-analysis.

Authors:  Lihua Liu; Shan Wang; Xiutang Cao; Jianchao Liu
Journal:  Tumour Biol       Date:  2014-08-27

7.  A cohort study of the prognostic and treatment predictive value of SATB2 expression in colorectal cancer.

Authors:  J Eberhard; A Gaber; S Wangefjord; B Nodin; M Uhlén; K Ericson Lindquist; K Jirström
Journal:  Br J Cancer       Date:  2012-02-14       Impact factor: 7.640

8.  BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.

Authors:  Emilie Jacque; Edina Schweighoffer; Victor L J Tybulewicz; Steven C Ley
Journal:  J Exp Med       Date:  2015-05-18       Impact factor: 14.307

9.  The mRNA expression of SATB1 and SATB2 in human breast cancer.

Authors:  Neill Patani; Wen Jiang; Robert Mansel; Robert Newbold; Kefah Mokbel
Journal:  Cancer Cell Int       Date:  2009-07-30       Impact factor: 5.722

10.  Plasma microRNAs, miR-223, miR-21 and miR-218, as novel potential biomarkers for gastric cancer detection.

Authors:  Bo-sheng Li; Yong-liang Zhao; Gang Guo; Wei Li; En-dong Zhu; Xiao Luo; Xu-hu Mao; Quan-ming Zou; Pei-wu Yu; Qian-fei Zuo; Na Li; Bin Tang; Kai-yun Liu; Bin Xiao
Journal:  PLoS One       Date:  2012-07-30       Impact factor: 3.240
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  7 in total

1.  SATB2 suppresses non-small cell lung cancer invasiveness by G9a.

Authors:  Yi-Nan Ma; Hai-Yan Zhang; Liang-Ru Fei; Mei-Yu Zhang; Cong-Cong Wang; Yuan Luo; Yu-Chen Han
Journal:  Clin Exp Med       Date:  2017-06-30       Impact factor: 3.984

Review 2.  SATB2-associated syndrome: Mechanisms, phenotype, and practical recommendations.

Authors:  Yuri A Zarate; Jennifer L Fish
Journal:  Am J Med Genet A       Date:  2016-10-24       Impact factor: 2.802

Review 3.  MAP Kinases Pathways in Gastric Cancer.

Authors:  Lucia Magnelli; Nicola Schiavone; Fabio Staderini; Alessio Biagioni; Laura Papucci
Journal:  Int J Mol Sci       Date:  2020-04-21       Impact factor: 5.923

Review 4.  Oncogenic and tumor suppressive roles of special AT-rich sequence-binding protein.

Authors:  Qiao Yi Chen; Max Costa
Journal:  J Carcinog       Date:  2018-04-05

5.  Molecular Mechanisms of Malignant Transformation by Low Dose Cadmium in Normal Human Bronchial Epithelial Cells.

Authors:  Laura Cartularo; Thomas Kluz; Lisa Cohen; Steven S Shen; Max Costa
Journal:  PLoS One       Date:  2016-05-17       Impact factor: 3.240

6.  Exosome-transferred LINC01559 promotes the progression of gastric cancer via PI3K/AKT signaling pathway.

Authors:  Liyan Wang; Xiaotong Bo; Xiaoyuan Yi; Xuhua Xiao; Qinghua Zheng; Lei Ma; Bin Li
Journal:  Cell Death Dis       Date:  2020-09-07       Impact factor: 8.469

7.  SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells.

Authors:  Weiwei Tao; Aili Zhang; Kui Zhai; Zhi Huang; Haidong Huang; Wenchao Zhou; Qian Huang; Xiaoguang Fang; Briana C Prager; Xiuxing Wang; Qiulian Wu; Andrew E Sloan; Manmeet S Ahluwalia; Justin D Lathia; Jennifer S Yu; Jeremy N Rich; Shideng Bao
Journal:  EMBO Mol Med       Date:  2020-10-30       Impact factor: 12.137
  7 in total

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