Literature DB >> 26507581

BEND3 mediates transcriptional repression and heterochromatin organization.

Abid Khan1, Supriya G Prasanth1.   

Abstract

Transcription repression plays a central role in gene regulation. Transcription repressors utilize diverse strategies to mediate transcriptional repression. We have recently demonstrated that BEND3 (BANP, E5R and Nac1 domain) protein represses rDNA transcription by stabilizing a NoRC component. We discuss the role of BEND3 as a global regulator of gene expression and propose a model whereby BEND3 associates with chromatin remodeling complexes to modulate gene expression and heterochromatin organization.

Entities:  

Keywords:  BEND3; NoRC; NuRD; rDNA; telomeres; transcription repression

Mesh：

Substances：

Year:  2015        PMID： 26507581      PMCID： PMC4802757          DOI： 10.1080/21541264.2015.1100228

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  29 in total

1.  The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription.

Authors:  Yonggang Zhou; Raffaella Santoro; Ingrid Grummt
Journal:  EMBO J       Date:  2002-09-02       Impact factor: 11.598

Review 2.  The role of chromatin during transcription.

Authors:  Bing Li; Michael Carey; Jerry L Workman
Journal:  Cell       Date:  2007-02-23       Impact factor: 41.582

Review 3.  The human Mi-2/NuRD complex and gene regulation.

Authors:  S A Denslow; P A Wade
Journal:  Oncogene       Date:  2007-08-13       Impact factor: 9.867

4.  BEN: a novel domain in chromatin factors and DNA viral proteins.

Authors:  Saraswathi Abhiman; Lakshminarayan M Iyer; L Aravind
Journal:  Bioinformatics       Date:  2008-01-18       Impact factor: 6.937

5.  NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.

Authors:  Y Xue; J Wong; G T Moreno; M K Young; J Côté; W Wang
Journal:  Mol Cell       Date:  1998-12       Impact factor: 17.970

6.  An Oct4-centered protein interaction network in embryonic stem cells.

Authors:  Debbie L C van den Berg; Tim Snoek; Nick P Mullin; Adam Yates; Karel Bezstarosti; Jeroen Demmers; Ian Chambers; Raymond A Poot
Journal:  Cell Stem Cell       Date:  2010-04-02       Impact factor: 24.633

7.  The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription.

Authors:  Raffaella Santoro; Junwei Li; Ingrid Grummt
Journal:  Nat Genet       Date:  2002-10-07       Impact factor: 38.330

8.  A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.

Authors:  J Taunton; C A Hassig; S L Schreiber
Journal:  Science       Date:  1996-04-19       Impact factor: 47.728

9.  Mbd3, a component of NuRD/Mi-2 complex, helps maintain pluripotency of mouse embryonic stem cells by repressing trophectoderm differentiation.

Authors:  Dongmei Zhu; Junshun Fang; Yanxin Li; Jian Zhang
Journal:  PLoS One       Date:  2009-11-03       Impact factor: 3.240

10.  The NuRD component Mbd3 is required for pluripotency of embryonic stem cells.

Authors:  Keisuke Kaji; Isabel Martín Caballero; Ruth MacLeod; Jennifer Nichols; Valerie A Wilson; Brian Hendrich
Journal:  Nat Cell Biol       Date:  2006-02-05       Impact factor: 28.824
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  10 in total

Review 1.  Genetic and epigenetic regulation of human aging and longevity.

Authors:  Brian J Morris; Bradley J Willcox; Timothy A Donlon
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2018-09-01       Impact factor: 5.187

2.  A BEN-domain protein and polycomb complex work coordinately to regulate transcription.

Authors:  Fredy Kurniawan; Supriya G Prasanth
Journal:  Transcription       Date:  2022-07-29

3.  Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis.

Authors:  Longfei Ma; Dan Xie; Mengcheng Luo; Xiwen Lin; Hengyu Nie; Jian Chen; Chenxu Gao; Shuguang Duo; Chunsheng Han
Journal:  Sci Adv       Date:  2022-05-25       Impact factor: 14.957

4.  BANP opens chromatin and activates CpG-island-regulated genes.

Authors:  Ralph S Grand; Lukas Burger; Cathrin Gräwe; Alicia K Michael; Luke Isbel; Daniel Hess; Leslie Hoerner; Vytautas Iesmantavicius; Sevi Durdu; Marco Pregnolato; Arnaud R Krebs; Sébastien A Smallwood; Nicolas Thomä; Michiel Vermeulen; Dirk Schübeler
Journal:  Nature       Date:  2021-07-07       Impact factor: 49.962

Review 5.  Acute Myeloid Leukemia-Related Proteins Modified by Ubiquitin and Ubiquitin-like Proteins.

Authors:  Sang-Soo Park; Kwang-Hyun Baek
Journal:  Int J Mol Sci       Date:  2022-01-03       Impact factor: 5.923

6.  Regulation of mitotic chromosome architecture and resolution of ultrafine anaphase bridges by PICH.

Authors:  Primrose Chanboonyasitt; Ying Wai Chan
Journal:  Cell Cycle       Date:  2021-09-16       Impact factor: 4.534

7.  BEND3 safeguards pluripotency by repressing differentiation-associated genes.

Authors:  Fredy Kurniawan; Neha Chetlangia; Mohammad Kamran; Christophe E Redon; Lorinc Pongor; Qinyu Sun; Yo-Chuen Lin; Vijay Mohan; Oways Shaqildi; Darya Asoudegi; Qinyu Hao; Abid Khan; Mirit I Aladjem; Kannanganattu V Prasanth; Supriya G Prasanth
Journal:  Proc Natl Acad Sci U S A       Date:  2022-03-01       Impact factor: 12.779

8.  Identification of Diagnostic Exosomal LncRNA-miRNA-mRNA Biomarkers in Colorectal Cancer Based on the ceRNA Network.

Authors:  Yajing Zhao; Xingguo Song; Xianrang Song; Li Xie
Journal:  Pathol Oncol Res       Date:  2022-09-16       Impact factor: 2.874

9.  A novel TPR-BEN domain interaction mediates PICH-BEND3 association.

Authors:  Ganesha P Pitchai; Manuel Kaulich; Anna H Bizard; Pablo Mesa; Qi Yao; Kata Sarlos; Werner W Streicher; Erich A Nigg; Guillermo Montoya; Ian D Hickson
Journal:  Nucleic Acids Res       Date:  2017-11-02       Impact factor: 16.971

10.  A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity.

Authors:  Samir H Barghout; Ahmed Aman; Kazem Nouri; Zachary Blatman; Karen Arevalo; Geethu E Thomas; Neil MacLean; Rose Hurren; Troy Ketela; Mehakpreet Saini; Moustafa Abohawya; Taira Kiyota; Rima Al-Awar; Aaron D Schimmer
Journal:  JCI Insight       Date:  2021-03-08
  10 in total

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