Komlavi Yayehd1, N'kenon W N'da1, Loïc Belle2, Vincent Bataille3, Michel Hanssen4, Pierre Leddet4, Jean-François Aupetit5, Philippe Commeau6, Emmanuelle Filippi7, Jean-Louis Georges8, Franck Albert9, Grégoire Rangé9, Patrick Meimoun10, Xavier Marcaggi11, Serge Baleynaud12, Olivier Nallet13, Alain Dibie14, Claude Barnay15, Bernard Jouve15, Maud Legrand16, Simon Cattan13, Geneviève Mulak17, Tabassome Simon18, Nicolas Danchin19, Jean-Jacques Dujardin20. 1. Department of Cardiology, Campus University Teaching Hospital, Lomé, Togo. 2. Department of Cardiology, Annecy Hospital, 74000 Annecy, France. Electronic address: loic.belle@wanadoo.fr. 3. Department of Cardiology and Epidemiology, Toulouse University Hospital, 31000 Toulouse, France. 4. Department of Cardiology, Haguenau Hospital, 67500 Haguenau, France. 5. Department of Cardiology, Saint-Joseph - Saint-Luc Hospital, 69000 Lyon, France. 6. Department of Cardiology, polyclinique Les Fleurs, 83190 Ollioules, France. 7. Department of Cardiology, Bretagne-Atlantique Hospital, 56000 Vannes, France. 8. Department of Cardiology, Versailles Hospital, 78150 Le Chesnay, France. 9. Department of Cardiology, Chartres Hospital, 28000 Chartres, France. 10. Department of Cardiology, Compiègne Hospital, 60200 Compiègne, France. 11. Department of Cardiology, Vichy Hospital, 03200 Vichy, France. 12. Department of Cardiology, Bretagne Hospital, 56100 Lorient, France. 13. Department of Cardiology, Le Raincy-Montfermeil Intercity Hospital, 93370 Montfermeil, France. 14. Institut mutualiste Montsouris, 75000 Paris, France. 15. Department of Cardiology, Pays d'Aix Hospital, 13100 Aix-en-Provence, France. 16. Department of Cardiology, Le Mans Hospital, 72000 Le Mans, France. 17. French Society of Cardiology, 75000 Paris, France. 18. Department of Clinical Pharmacology and Clinical Research, Saint-Antoine University Hospital, 75000 Paris, France. 19. Department of Cardiology, Georges-Pompidou University Hospital, 75000 Paris, France. 20. Department of Cardiology, Douai Hospital, 59500 Douai, France.
Abstract
BACKGROUND: Takotsubo cardiomyopathy (TTC) is a rare condition characterized by a sudden temporary weakening of the heart. TTC can mimic acute myocardial infarction and is associated with a minimal release of myocardial biomarkers in the absence of obstructive coronary artery disease. AIMS: To provide an extensive description of patients admitted to hospital for TTC throughout France and to study the management and outcomes of these patients. METHODS: In 14 non-academic hospitals, we collected clinical, electrocardiographic, biological, psychological and therapeutic data in patients with a diagnosis of TTC according to the Mayo Clinic criteria. RESULTS: Of 117 patients, 91.5% were women, mean ± SD age was 71.4 ± 12.1 years and the prevalence of risk factors was high (hypertension: 57.9%, dyslipidaemia: 33.0%, diabetes: 11.5%, obesity: 11.5%). The most common initial symptoms were chest pain (80.5%) and dyspnoea (24.1%). A triggering psychological event was detected in 64.3% of patients. ST-segment elevation was found in 41.7% of patients and T-wave inversion in 71.6%. Anterior leads were most frequently associated with ST-segment elevation, whereas T-wave inversion was more commonly associated with lateral leads, and Q-waves with septal leads. The ratio of peak B-type natriuretic peptide (BNP) or N-terminal prohormone BNP (NT-proBNP) level to peak troponin level was 1.01. No deaths occurred during the hospital phase. After 1 year of follow-up, 3 of 109 (2.8%) patients with available data died, including one cardiovascular death. Rehospitalizations occurred in 17.4% of patients: 2.8% due to acute heart failure and 14.7% due to non-cardiovascular causes. There was no recurrence of TTC. CONCLUSIONS: This observational study of TTC included primarily women with atherosclerotic risk factors and mental stress. T-wave inversion was more common than ST-segment elevation. There were few adverse cardiovascular outcomes in these patients after 1-year follow-up.
BACKGROUND:Takotsubo cardiomyopathy (TTC) is a rare condition characterized by a sudden temporary weakening of the heart. TTC can mimic acute myocardial infarction and is associated with a minimal release of myocardial biomarkers in the absence of obstructive coronary artery disease. AIMS: To provide an extensive description of patients admitted to hospital for TTC throughout France and to study the management and outcomes of these patients. METHODS: In 14 non-academic hospitals, we collected clinical, electrocardiographic, biological, psychological and therapeutic data in patients with a diagnosis of TTC according to the Mayo Clinic criteria. RESULTS: Of 117 patients, 91.5% were women, mean ± SD age was 71.4 ± 12.1 years and the prevalence of risk factors was high (hypertension: 57.9%, dyslipidaemia: 33.0%, diabetes: 11.5%, obesity: 11.5%). The most common initial symptoms were chest pain (80.5%) and dyspnoea (24.1%). A triggering psychological event was detected in 64.3% of patients. ST-segment elevation was found in 41.7% of patients and T-wave inversion in 71.6%. Anterior leads were most frequently associated with ST-segment elevation, whereas T-wave inversion was more commonly associated with lateral leads, and Q-waves with septal leads. The ratio of peak B-type natriuretic peptide (BNP) or N-terminal prohormone BNP (NT-proBNP) level to peak troponin level was 1.01. No deaths occurred during the hospital phase. After 1 year of follow-up, 3 of 109 (2.8%) patients with available data died, including one cardiovascular death. Rehospitalizations occurred in 17.4% of patients: 2.8% due to acute heart failure and 14.7% due to non-cardiovascular causes. There was no recurrence of TTC. CONCLUSIONS: This observational study of TTC included primarily women with atherosclerotic risk factors and mental stress. T-wave inversion was more common than ST-segment elevation. There were few adverse cardiovascular outcomes in these patients after 1-year follow-up.
Authors: Athanasios Papadis; Stefano Svab; Nicolas Brugger; Jonas Lanz; Robert von Arx; Konstantinos Stamou; Stefanos Sakellaropoulos Journal: Cardiol Res Date: 2021-12-28
Authors: Anastasiia V Bairashevskaia; Sofiya Y Belogubova; Mikhail R Kondratiuk; Daria S Rudnova; Susanna S Sologova; Olga I Tereshkina; Esma I Avakyan Journal: Int J Cardiol Heart Vasc Date: 2022-03-07
Authors: Sara Moscatelli; Fabrizio Montecucco; Federico Carbone; Alberto Valbusa; Laura Massobrio; Italo Porto; Claudio Brunelli; Gian Marco Rosa Journal: Biomed Res Int Date: 2019-10-30 Impact factor: 3.411