| Literature DB >> 26507211 |
Jun Xiang Ong1, Siew Qi Yap1, Daniel Yuan Qiang Wong1, Chee Fei Chin1, Wee Han Ang2.
Abstract
Kinetically-inert Pt(IV) carboxylate complexes have emerged in recent years as candidates for the development of next-generation platinum anticancer drugs. Being native prodrugs of clinically-important Pt(II) chemotherapeutic agents, the Pt(IV) scaffold can be exploited to incorporate additional functionalities while keeping the Pt(II) pharmacophore intact. This mini-review examines recent work performed to illuminate the mechanism of Pt(IV) prodrug activation and their use as versatile platforms for targeted chemotherapy.Entities:
Year: 2015 PMID： 26507211 DOI： 10.2533/chimia.2015.100
Source DB: PubMed Journal: Chimia (Aarau) ISSN： 0009-4293 Impact factor: 1.509