Antonios Marmarinos1, Anastasia Garoufi2, Adamantia Panagoulia3, Stamatina Dimou4, Antonis Drakatos3, Irene Paraskakis5, Dimitrios Gourgiotis6. 1. Laboratory of Clinical Biochemistry-Molecular Diagnostics, Second Department of Pediatrics, Athens University Medical School, "P & A Kyriakou" Children's Hospital Athens, Attica, Greece. 2. Second Department of Pediatrics, Athens University Medical School, "P & A Kyriakou" Children's Hospital, Athens, Attica, Greece. 3. Biochemistry Laboratory, "P & A Kyriakou" Children's Hospital, Athens, Attica, Greece. 4. Biochemistry Laboratory, "P & A Kyriakou" Children's Hospital, Department of Clinical Biochemistry, Athens, Attica, Greece. 5. Department of Clinical Microbiology, "P & A Kyriakou" Children's Hospital, Athens, Attica, Greece. 6. Second Department of Pediatrics, Athens University Medical School, "P & A Kyriakou" Children's Hospital, Athens, Attica, Greece. Electronic address: dgourg@med.uoa.gr.
Abstract
OBJECTIVES: Cystatin-C is considered a more sensitive and specific marker of kidney function than creatinine since it can diagnose patients with earlier-stage of renal dysfunction. The aim of this study is to determine the levels of Cystatin-C in healthy children and adolescents as well as any correlations to age, gender, body-mass index (BMI) and blood pressure (BP). DESIGN AND METHODS: Cystatin-C was measured in 536 healthy Greek children and adolescents (295 males and 241 females) using a nephelometric immunoassay. Additionally, the age, body mass index and blood pressure was recorded for each subject. RESULTS: Overall, the mean serum Cystatin-C level was 0.79 ± 0.10 mg/L. Cystatin-C was found to be statistically significantly lower in females than in males (p < 0.001) as well as in prepubertal children compared to adolescents (p < 0.001). Higher values of Cystatin-C were observed in subjects with increased BMI (p < 0.001). Neither systolic nor diastolic blood pressure was found to significantly affect Cystatin-C levels. CONCLUSIONS: The levels of Cystatin-C were statistically significantly higher in males, compared to age-matched females and also positively correlated with age and BMI.
OBJECTIVES:Cystatin-C is considered a more sensitive and specific marker of kidney function than creatinine since it can diagnose patients with earlier-stage of renal dysfunction. The aim of this study is to determine the levels of Cystatin-C in healthy children and adolescents as well as any correlations to age, gender, body-mass index (BMI) and blood pressure (BP). DESIGN AND METHODS: Cystatin-C was measured in 536 healthy Greek children and adolescents (295 males and 241 females) using a nephelometric immunoassay. Additionally, the age, body mass index and blood pressure was recorded for each subject. RESULTS: Overall, the mean serum Cystatin-C level was 0.79 ± 0.10 mg/L. Cystatin-C was found to be statistically significantly lower in females than in males (p < 0.001) as well as in prepubertal children compared to adolescents (p < 0.001). Higher values of Cystatin-C were observed in subjects with increased BMI (p < 0.001). Neither systolic nor diastolic blood pressure was found to significantly affect Cystatin-C levels. CONCLUSIONS: The levels of Cystatin-C were statistically significantly higher in males, compared to age-matched females and also positively correlated with age and BMI.
Entities:
Keywords:
Creatinine; Markers of renal function; Obesity; Overweight; Puberty
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