Literature DB >> 26505672

A perspective on stem cell modeling of amyotrophic lateral sclerosis.

A Sophie de Boer1,2, Kevin Eggan1.   

Abstract

Amyotrophic lateral sclerosis is a complex neurodegenerative disease. Limitations in animal models have impeded progress in studying disease pathology and potential drug discovery. Here, we will review recent advances in the development of stem cell models for the study of ALS. Additionally, we will discuss the progress toward therapeutic development derived from these stem cell based assays.

Entities:  

Keywords:  Amyotrophic Lateral Sclerosis; astrocyte; embryonic stem cells; glia; induced pluripotent stem cells; microglia; motor neuron

Mesh：

Substances：

Year:  2015        PMID： 26505672      PMCID： PMC4825790          DOI： 10.1080/15384101.2015.1093712

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  80 in total

1.  Directed differentiation of embryonic stem cells into motor neurons.

Authors:  Hynek Wichterle; Ivo Lieberam; Jeffery A Porter; Thomas M Jessell
Journal:  Cell       Date:  2002-08-09       Impact factor: 41.582

2.  Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model.

Authors:  Francesco Paolo Di Giorgio; Monica A Carrasco; Michelle C Siao; Tom Maniatis; Kevin Eggan
Journal:  Nat Neurosci       Date:  2007-04-15       Impact factor: 24.884

3.  Accelerated high-yield generation of limb-innervating motor neurons from human stem cells.

Authors:  Mackenzie W Amoroso; Gist F Croft; Damian J Williams; Sean O'Keeffe; Monica A Carrasco; Anne R Davis; Laurent Roybon; Derek H Oakley; Tom Maniatis; Christopher E Henderson; Hynek Wichterle
Journal:  J Neurosci       Date:  2013-01-09       Impact factor: 6.167

4.  Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

Authors:  M E Ripps; G W Huntley; P R Hof; J H Morrison; J W Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1995-01-31       Impact factor: 11.205

5.  Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia.

Authors:  Qin Xiao; Weihua Zhao; David R Beers; Albert A Yen; Wenjie Xie; Jenny S Henkel; Stanley H Appel
Journal:  J Neurochem       Date:  2007-06-07       Impact factor: 5.372

6.  Erosion of dosage compensation impacts human iPSC disease modeling.

Authors:  Shila Mekhoubad; Christoph Bock; A Sophie de Boer; Evangelos Kiskinis; Alexander Meissner; Kevin Eggan
Journal:  Cell Stem Cell       Date:  2012-05-04       Impact factor: 24.633

7.  Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons.

Authors:  Hong Chen; Kun Qian; Zhongwei Du; Jingyuan Cao; Andrew Petersen; Huisheng Liu; Lisle W Blackbourn; CindyTzu-Ling Huang; Anthony Errigo; Yingnan Yin; Jianfeng Lu; Melvin Ayala; Su-Chun Zhang
Journal:  Cell Stem Cell       Date:  2014-04-03       Impact factor: 24.633

8.  Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.

Authors:  P H Tu; P Raju; K A Robinson; M E Gurney; J Q Trojanowski; V M Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-02       Impact factor: 11.205

9.  Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.

Authors:  Han-Xiang Deng; Wenjie Chen; Seong-Tshool Hong; Kym M Boycott; George H Gorrie; Nailah Siddique; Yi Yang; Faisal Fecto; Yong Shi; Hong Zhai; Hujun Jiang; Makito Hirano; Evadnie Rampersaud; Gerard H Jansen; Sandra Donkervoort; Eileen H Bigio; Benjamin R Brooks; Kaouther Ajroud; Robert L Sufit; Jonathan L Haines; Enrico Mugnaini; Margaret A Pericak-Vance; Teepu Siddique
Journal:  Nature       Date:  2011-08-21       Impact factor: 49.962

10.  Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

Authors:  Sami J Barmada; Andrea Serio; Arpana Arjun; Bilada Bilican; Aaron Daub; D Michael Ando; Andrey Tsvetkov; Michael Pleiss; Xingli Li; Daniel Peisach; Christopher Shaw; Siddharthan Chandran; Steven Finkbeiner
Journal:  Nat Chem Biol       Date:  2014-06-29       Impact factor: 15.040
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  8 in total

1.  A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.

Authors:  Luca Sala; Zhiyi Yu; Dorien Ward-van Oostwaard; Jacobus Pd van Veldhoven; Alessandra Moretti; Karl-Ludwig Laugwitz; Christine L Mummery; Adriaan P IJzerman; Milena Bellin
Journal:  EMBO Mol Med       Date:  2016-09-01       Impact factor: 12.137

2.  Myogenic differentiation of VCP disease-induced pluripotent stem cells: A novel platform for drug discovery.

Authors:  Katrina J Llewellyn; Angèle Nalbandian; Lan N Weiss; Isabela Chang; Howard Yu; Bibo Khatib; Baichang Tan; Vanessa Scarfone; Virginia E Kimonis
Journal:  PLoS One       Date:  2017-06-02       Impact factor: 3.240

3.  Proteasome impairment in neural cells derived from HMSN-P patient iPSCs.

Authors:  Nagahisa Murakami; Keiko Imamura; Yuishin Izumi; Naohiro Egawa; Kayoko Tsukita; Takako Enami; Takuya Yamamoto; Toshitaka Kawarai; Ryuji Kaji; Haruhisa Inoue
Journal:  Mol Brain       Date:  2017-02-15       Impact factor: 4.041

4.  Aggregated SOD1 causes selective death of cultured human motor neurons.

Authors:  Chen Benkler; Alison L O'Neil; Susannah Slepian; Fang Qian; Paul H Weinreb; Lee L Rubin
Journal:  Sci Rep       Date:  2018-11-06       Impact factor: 4.379

5.  Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS.

Authors:  Ilary Allodi; Laura Comley; Susanne Nichterwitz; Monica Nizzardo; Chiara Simone; Julio Aguila Benitez; Ming Cao; Stefania Corti; Eva Hedlund
Journal:  Sci Rep       Date:  2016-05-16       Impact factor: 4.379

6.  Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis.

Authors:  Danilo B Medinas; Jose V González; Paulina Falcon; Claudio Hetz
Journal:  Front Mol Neurosci       Date:  2017-07-05       Impact factor: 5.639

7.  Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials.

Authors:  Leonard H van den Berg; Eric Sorenson; Gary Gronseth; Eric A Macklin; Jinsy Andrews; Robert H Baloh; Michael Benatar; James D Berry; Adriano Chio; Philippe Corcia; Angela Genge; Amelie K Gubitz; Catherine Lomen-Hoerth; Christopher J McDermott; Erik P Pioro; Jeffrey Rosenfeld; Vincenzo Silani; Martin R Turner; Markus Weber; Benjamin Rix Brooks; Robert G Miller; Hiroshi Mitsumoto
Journal:  Neurology       Date:  2019-03-08       Impact factor: 9.910

Review 8.  Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases.

Authors:  Dorit Trudler; Swagata Ghatak; Stuart A Lipton
Journal:  Int J Mol Sci       Date:  2021-07-30       Impact factor: 5.923
  8 in total

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