Hypertension in the aged: a pathophysiologic basis for treatment.

According to major surveys, hypertension is found in over half the population aged 65 years or over. In this age group, systolic blood pressure is at least as important as diastolic blood pressure as a predictor of cardiovascular morbidity and mortality. Overall, the presence of hypertension is associated with approximately a threefold increase in the likelihood of major events. Differing factors contribute to the hypertension. Loss of proximal arterial compliance, affecting the larger conduit vessels, occurs often with aging and explains the tendency for systolic pressure to increase while diastolic pressure remains constant or even decreases. A loss of baroreceptor sensitivity also may contribute to hypertension. There is an increase in responsiveness of the sympathetic nervous system and an enhanced sensitivity to its effects in the elderly, perhaps reflecting a decline in the buffering activity of peripheral vascular beta receptors. It is possible, too, that sodium retention may contribute to hypertension in some older patients. Although diuretics traditionally have been the mainstay of treatment in these patients, it is now recognized that other classes of antihypertensive agents may be equally as effective yet less prone to metabolic or symptomatic adverse events. Sympatholytic drugs, calcium channel blockers and angiotensin-converting enzyme inhibitors, either as monotherapy or in combination with low-dose diuretics, have been shown to be efficacious in the elderly. These agents also can produce regression of left ventricular hypertrophy, an additional property that may contribute to a reduction in serious cardiac complications.