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Literature DB >> 26504670

β3-adrenoreceptor and tumor microenvironment: a new hub.

Abstract

The achievement of malignant traits in several cancers is associated with tumor microenvironment reactivity. New evidence show that the stress hormone noradrenaline enhances melanoma microenvironment reactivity, mainly acting through β3-adrenoreceptors (β2-ARs), favoring recruitment of cancer-associated fibroblasts, M2-macrophages, bone marrow-derived precursors, These events concur in sustaining a pro-inflammatory and pro-angiogenic milieu, finally boosting melanoma malignancy.

Entities: Chemical Disease Gene

Keywords: beta-adrenoreceptors; cancer associated fibroblasts; inflammation; mesenchymal stem cells; stress; tumor microenvironment

Year: 2015 PMID： 26504670 PMCID： PMC4589043 DOI： 10.1080/2162402X.2015.1026532

Source DB: PubMed Journal: Oncoimmunology ISSN： 2162-4011 Impact factor: 8.110

10 in total

1. Beta blockers and breast cancer mortality: a population- based study.

Authors: Thomas I Barron; Roisin M Connolly; Linda Sharp; Kathleen Bennett; Kala Visvanathan
Journal: J Clin Oncol Date: 2011-05-31 Impact factor: 44.544

Review 2. Molecular pathways: beta-adrenergic signaling in cancer.

Authors: Steven W Cole; Anil K Sood
Journal: Clin Cancer Res Date: 2011-12-20 Impact factor: 12.531

3. Tumor microenvironment and metabolism in prostate cancer.

Authors: Paola Chiarugi; Paolo Paoli; Paolo Cirri
Journal: Semin Oncol Date: 2014-03-05 Impact factor: 4.929

4. Functional involvement of β3-adrenergic receptors in melanoma growth and vascularization.

Authors: Massimo Dal Monte; Giovanni Casini; Luca Filippi; Grazia Paola Nicchia; Maria Svelto; Paola Bagnoli
Journal: J Mol Med (Berl) Date: 2013-08-02 Impact factor: 4.599

Review 5. Infantile hemangiomas, retinopathy of prematurity and cancer: a common pathogenetic role of the β-adrenergic system.

Authors: Luca Filippi; Massimo Dal Monte; Giovanni Casini; Marta Daniotti; Federica Sereni; Paola Bagnoli
Journal: Med Res Rev Date: 2014-12-19 Impact factor: 12.944

6. CO2 asphyxia increases plasma norepinephrine in rats via sympathetic nerves.

Authors: V Borovsky; M Herman; G Dunphy; A Caplea; D Ely
Journal: Am J Physiol Date: 1998-01

7. β-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines.

Authors: Silvia Moretti; Daniela Massi; Valentina Farini; Gianna Baroni; Matteo Parri; Stefania Innocenti; Roberto Cecchi; Paola Chiarugi
Journal: Lab Invest Date: 2013-01-14 Impact factor: 5.662

8. Association between use of β-blockers and prostate cancer-specific survival: a cohort study of 3561 prostate cancer patients with high-risk or metastatic disease.

Authors: Helene Hartvedt Grytli; Morten Wang Fagerland; Sophie D Fosså; Kristin Austlid Taskén
Journal: Eur Urol Date: 2013-01-14 Impact factor: 20.096

9. Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression.

Authors: G Comito; E Giannoni; C P Segura; P Barcellos-de-Souza; M R Raspollini; G Baroni; M Lanciotti; S Serni; P Chiarugi
Journal: Oncogene Date: 2013-06-03 Impact factor: 9.867

10. Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression.

Authors: Maura Calvani; Floriane Pelon; Giuseppina Comito; Maria Letizia Taddei; Silvia Moretti; Stefania Innocenti; Romina Nassini; Gianni Gerlini; Lorenzo Borgognoni; Franco Bambi; Elisa Giannoni; Luca Filippi; Paola Chiarugi
Journal: Oncotarget Date: 2015-03-10

10 in total

3 in total

Review 1. Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments.

Authors: Wentao Tian; Yi Liu; Chenghui Cao; Yue Zeng; Yue Pan; Xiaohan Liu; Yurong Peng; Fang Wu
Journal: Front Cell Dev Biol Date: 2021-11-19

2. Editorial: Tumor microenvironment signaling networks in pathophysiology and therapeutics.

Authors: Francesca Pirini; Daniele Vergara; Paola Parrella
Journal: Front Oncol Date: 2022-09-08 Impact factor: 5.738

3. β3-Adrenoreceptor Blockade Reduces Hypoxic Myeloid Leukemic Cells Survival and Chemoresistance.

Authors: Maura Calvani; Annalisa Dabraio; Gennaro Bruno; Veronica De Gregorio; Marcella Coronnello; Costanza Bogani; Sara Ciullini; Giancarlo la Marca; Marina Vignoli; Paola Chiarugi; Margherita Nardi; Alessandro Maria Vannucchi; Luca Filippi; Claudio Favre
Journal: Int J Mol Sci Date: 2020-06-12 Impact factor: 5.923

3 in total