Nicholas S Hopkinson1, Nicholas Hart2, Gisli Jenkins3, Alan Smyth4. 1. NIHR Respiratory Biomedical Research Unit at the Royal Brompton & Harefield NHS Foundation Trust and Imperial College, London, UK. 2. Lane Fox Respiratory Unit, GSTFT and KCL Biomedical Research Centre, London, UK. 3. Centre for Respiratory Research, University of Nottingham, Nottingham, UK. 4. Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK.