Lucia Manganaro1, Emanuela Anastasi2, Maria Grazia Porpora3, Valeria Vinci4, Matteo Saldari4, Silvia Bernardo4, Laura Ballesio4, Paolo Sollazzo4, Irene Pecorella4, Nicola Recchia5, Fabrizio Stracci6, Pierluigi Benedetti Panici3, Antonio Angeloni2, Carlo Catalano4, Michele Scialpi5. 1. Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy lucia.manganaro@uniroma1.it. 2. Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. 3. Department of Obstetrics, Gynecology and Urologic Sciences, Sapienza University of Rome, Rome, Italy. 4. Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy. 5. Division of Radiology, Department of Surgical and Biomedical Sciences, Perugia University, S. Maria della Misericordia Hospital, Perugia, Italy. 6. Division of Hygiene and Public Health, Department of Experimental Medicine, Perugia University, S. Maria della Misericordia Hospital, Perugia, Italy.
Abstract
BACKGROUND/AIM: Aim of the present study was to assess the diagnostic value of unenhanced biparametric magnetic resonance imaging (Bp-MRI) as adjunct to CA125 and human epididymis protein 4 (HE4) in the characterization of large ovarian masses. PATIENTS AND METHODS: Bp-MRI and dynamic contrast-enhanced (DCE) imaging of 53 patients with large ovarian masses were retrospectively analyzed and compared to histological diagnosis. The results of Bp-MRI and DCE were assessed by two readers in consensus for each technique individually compared to each other and then with HE4 and CA125. RESULTS: Sensitivity, specificity, negative predictive values and positive predictive values for Bp-MRI and DCE were 92.3%, 91.4%, 94.1%, 88.9% and 84.6%, 94.3%, 89.2%, 91.7%, respectively. Both Bp-MRI and DCE were significant predictors of outcome. Among biomarkers, HE4 was significant. Considering the area under receiver operating characteristic curve the model including Bp-MRI and HE4 was not significantly different from the model including DCE and HE4. CONCLUSION: Bp-MRI in addition to HE4, especially in women of pre-menopausal age, could improve the characterization of large ovarian masses. Copyright
BACKGROUND/AIM: Aim of the present study was to assess the diagnostic value of unenhanced biparametric magnetic resonance imaging (Bp-MRI) as adjunct to CA125 and humanepididymis protein 4 (HE4) in the characterization of large ovarian masses. PATIENTS AND METHODS: Bp-MRI and dynamic contrast-enhanced (DCE) imaging of 53 patients with large ovarian masses were retrospectively analyzed and compared to histological diagnosis. The results of Bp-MRI and DCE were assessed by two readers in consensus for each technique individually compared to each other and then with HE4 and CA125. RESULTS: Sensitivity, specificity, negative predictive values and positive predictive values for Bp-MRI and DCE were 92.3%, 91.4%, 94.1%, 88.9% and 84.6%, 94.3%, 89.2%, 91.7%, respectively. Both Bp-MRI and DCE were significant predictors of outcome. Among biomarkers, HE4 was significant. Considering the area under receiver operating characteristic curve the model including Bp-MRI and HE4 was not significantly different from the model including DCE and HE4. CONCLUSION:Bp-MRI in addition to HE4, especially in women of pre-menopausal age, could improve the characterization of large ovarian masses. Copyright