Anil Agarwal1, Mohd Shafi Bhat2, Anubrat Kumar2, Abbas Shaharyar2, Madhusudhan Mishra2, Rajeev Yadav3. 1. Specialist, Department of Pediatric Orthopedics, Chacha Nehru Bal Chikitsalaya, Delhi, India dranilagarwal08@gmail.com. 2. Senior Resident, Department of Paediatric Orthopedics, Chacha Nehru Bal Chikitsalaya, Delhi, India. 3. Associate Professor, Department of Community Medicine, SMS Medical College, Jaipur, Rajasthan, India).
Abstract
INTRODUCTION: *Work attributed to Department of Pediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi-110031(India)This study tested the hypothesis whether the lymphocyte/monocyte ratio (L/M ratio) altered significantly during treatment of paediatric osteoarticular tuberculosis (OATB) for it to be a useful monitor of the response to therapy. MATERIAL AND METHODS: Thirty immunocompetent paediatric patients with OATB treated with 6 months of uninterrupted multidrug anti-tubercular treatment with resultant clinical and radiological healing of the lesion were included. Haemoglobin, total leucocyte, monocyte and lymphocyte count, and erythrocyte sedimentation rate (ESR) were collected at 0, 2 and 6 months, and were analysed. RESULTS: The L/M ratio altered from high (11) at the start of treatment towards normalisation (9) at 2 months and (7.7) at 6 months. There was no correlation with declining ESR levels. CONCLUSIONS: The L/M ratio may have potential as an effective biomarker response.
INTRODUCTION: *Work attributed to Department of Pediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi-110031(India)This study tested the hypothesis whether the lymphocyte/monocyte ratio (L/M ratio) altered significantly during treatment of paediatric osteoarticular tuberculosis (OATB) for it to be a useful monitor of the response to therapy. MATERIAL AND METHODS: Thirty immunocompetent paediatric patients with OATB treated with 6 months of uninterrupted multidrug anti-tubercular treatment with resultant clinical and radiological healing of the lesion were included. Haemoglobin, total leucocyte, monocyte and lymphocyte count, and erythrocyte sedimentation rate (ESR) were collected at 0, 2 and 6 months, and were analysed. RESULTS: The L/M ratio altered from high (11) at the start of treatment towards normalisation (9) at 2 months and (7.7) at 6 months. There was no correlation with declining ESR levels. CONCLUSIONS: The L/M ratio may have potential as an effective biomarker response.
Authors: Marco Pio La Manna; Valentina Orlando; Francesco Dieli; Paola Di Carlo; Antonio Cascio; Gilda Cuzzi; Fabrizio Palmieri; Delia Goletti; Nadia Caccamo Journal: PLoS One Date: 2017-02-16 Impact factor: 3.240