Literature DB >> 26503171

New tricks from an old dog: Another synaptotoxic fragment from APP.

Sheue-Houy Tyan1, Edward H Koo1,2.   

Abstract

In a surprising twist, a hitherto unrecognized cleavage of the amyloid precursor protein (APP) by η-secretase, followed by α- or β-secretase cleavage releases a novel APP proteolytic fragment, Aη, which causes synaptic injury.

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Year:  2015        PMID： 26503171      PMCID： PMC4650427          DOI： 10.1038/cr.2015.125

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  7 in total

1.  Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.

Authors:  Haizhi Wang; Nianli Sang; Can Zhang; Ramesh Raghupathi; Rudolph E Tanzi; Aleister Saunders
Journal:  Biochemistry       Date:  2015-04-28       Impact factor: 3.162

2.  Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's disease.

Authors:  Erik Portelius; Maria Olsson; Gunnar Brinkmalm; Ulla Rüetschi; Niklas Mattsson; Ulf Andreasson; Johan Gobom; Ann Brinkmalm; Mikko Hölttä; Kaj Blennow; Henrik Zetterberg
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

3.  A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion.

Authors:  J Ghiso; A Rostagno; J E Gardella; L Liem; P D Gorevic; B Frangione
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857

Review 4.  The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes.

Authors:  Hoang S Nhan; Karen Chiang; Edward H Koo
Journal:  Acta Neuropathol       Date:  2014-10-07       Impact factor: 17.088

5.  Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.

Authors:  Alfred T Welzel; John E Maggio; Ganesh M Shankar; Donald E Walker; Beth L Ostaszewski; Shaomin Li; Igor Klyubin; Michael J Rowan; Peter Seubert; Dominic M Walsh; Dennis J Selkoe
Journal:  Biochemistry       Date:  2014-06-24       Impact factor: 3.162

6.  η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Authors:  Michael Willem; Sabina Tahirovic; Marc Aurel Busche; Saak V Ovsepian; Magda Chafai; Scherazad Kootar; Daniel Hornburg; Lewis D B Evans; Steven Moore; Anna Daria; Heike Hampel; Veronika Müller; Camilla Giudici; Brigitte Nuscher; Andrea Wenninger-Weinzierl; Elisabeth Kremmer; Michael T Heneka; Dietmar R Thal; Vilmantas Giedraitis; Lars Lannfelt; Ulrike Müller; Frederick J Livesey; Felix Meissner; Jochen Herms; Arthur Konnerth; Hélène Marie; Christian Haass
Journal:  Nature       Date:  2015-08-31       Impact factor: 49.962

7.  Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.

Authors:  Tracy L Young-Pearse; Allen C Chen; Rui Chang; Cesar Marquez; Dennis J Selkoe
Journal:  Neural Dev       Date:  2008-06-23       Impact factor: 3.842
  7 in total
  2 in total

1.  Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells.

Authors:  J Chung; G Phukan; D Vergote; A Mohamed; M Maulik; M Stahn; R J Andrew; G Thinakaran; E Posse de Chaves; S Kar
Journal:  Mol Cell Biol       Date:  2018-05-15       Impact factor: 4.272

Review 2.  Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.

Authors:  Simone Eggert; Carolin Thomas; Stefan Kins; Guido Hermey
Journal:  Mol Neurobiol       Date:  2017-10-27       Impact factor: 5.590
  2 in total

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