Martina Studer1, Barbara Goeggel Simonetti1, Theda Heinks1, Maja Steinlin1, Alexander Leichtle2, Steffen Berger3, Alexander Joeris3. 1. a Department of Paediatric Neurology , Development & Rehabilitation, University Children's Hospital Bern , Bern , Switzerland . 2. b Department of Clinical Chemistry , University Hospital Bern , Bern , Switzerland , and. 3. c Department of Paediatric Surgery , University Children's Hospital Bern , Bern , Switzerland.
Abstract
OBJECTIVE: This study explored whether acute serum marker S100B is related with post-concussive symptoms (PCS) and neuropsychological performance 4 months after paediatric mild traumatic brain injury (mTBI). RESEARCH DESIGN AND METHODS: This prospective short-term longitudinal study investigated children (aged 6-16 years) with mTBI (n = 36, 16 males) and children with orthopaedic injuries (OI, n = 27, 18 males) as a control group. S100B in serum was measured during the acute phase and was correlated with parent-rated PCS and neuropsychological performance 4 months after the injury. MAIN OUTCOMES AND RESULTS: The results revealed no between-group difference regarding acute S100B serum concentration. In children after mTBI, group-specific significant Spearman correlations were found between S100B and post-acute cognitive PCS (r = 0.54, p = 0.001) as well as S100B and verbal memory performance (r = -0.47, p = 0.006). In children after OI, there were insignificant positive relations between S100B and post-acute somatic PCS. In addition, insignificant positive correlations were found between neuropsychological outcome and S100B in children after OI. CONCLUSIONS: S100B was not specific for mild brain injuries and may also be elevated after OI. The group-specific association between S100B and ongoing cognitive PCS in children after mTBI should motivate to examine further the role of S100B as a diagnostic biomarker in paediatric mTBI.
OBJECTIVE: This study explored whether acute serum marker S100B is related with post-concussive symptoms (PCS) and neuropsychological performance 4 months after paediatric mild traumatic brain injury (mTBI). RESEARCH DESIGN AND METHODS: This prospective short-term longitudinal study investigated children (aged 6-16 years) with mTBI (n = 36, 16 males) and children with orthopaedic injuries (OI, n = 27, 18 males) as a control group. S100B in serum was measured during the acute phase and was correlated with parent-rated PCS and neuropsychological performance 4 months after the injury. MAIN OUTCOMES AND RESULTS: The results revealed no between-group difference regarding acute S100B serum concentration. In children after mTBI, group-specific significant Spearman correlations were found between S100B and post-acute cognitive PCS (r = 0.54, p = 0.001) as well as S100B and verbal memory performance (r = -0.47, p = 0.006). In children after OI, there were insignificant positive relations between S100B and post-acute somatic PCS. In addition, insignificant positive correlations were found between neuropsychological outcome and S100B in children after OI. CONCLUSIONS:S100B was not specific for mild brain injuries and may also be elevated after OI. The group-specific association between S100B and ongoing cognitive PCS in children after mTBI should motivate to examine further the role of S100B as a diagnostic biomarker in paediatric mTBI.
Authors: Jamie Kearns; Aisling M Ross; Darragh R Walsh; Rachel M Cahalane; Rita Hinchion; Maria C Ryan; Elaine Conway; Tom M Comyns; Ian C Kenny; Eibhlís M O'Connor; Kieran D McGourty; John Joseph Eugene Mulvihill Journal: BMJ Open Sport Exerc Med Date: 2020-11-26
Authors: Divine C Nwafor; Allison L Brichacek; Chase H Foster; Brandon P Lucke-Wold; Ahsan Ali; Mark A Colantonio; Candice M Brown; Rabia Qaiser Journal: J Cent Nerv Syst Dis Date: 2022-05-22
Authors: Nicole A Toney; Michael J Bell; Steven H Belle; Regina M Hardison; Norberto Rodriguez-Baez; Kathleen M Loomes; Yoram Vodovotz; Ruben Zamora; Robert H Squires Journal: J Pediatr Gastroenterol Nutr Date: 2019-07 Impact factor: 2.839