| Literature DB >> 26501166 |
Sara Bagherifard1,2,3,4, Ali Tamayol1,2,5, Pooria Mostafalu6, Mohsen Akbari1,2,5,7, Mattia Comotto1,2, Nasim Annabi1,2,5,8, Masoumeh Ghaderi1,2, Sameer Sonkusale6, Mehmet R Dokmeci1,2,5, Ali Khademhosseini1,2,5,9.
Abstract
Topical administration of drugs and growth factors in a controlled fashion can improve the healing process during skin disorders and chronic wounds. To achieve this goal, a dermal patch is engineered that utilizes thermoresponsive drug microcarriers encapsulated within a hydrogel layer attached to a flexible heater with integrated electronic heater control circuitry. The engineered patch conformally covers the wound area and enables controlled drug delivery by electronically adjusting the temperature of the hydrogel layer. The drugs are encapsulated inside microparticles in order to control their release rates. These monodisperse thermoresponsive microparticles containing active molecules are fabricated using a microfluidic device. The system is used to release two different active molecules with molecular weights similar to drugs and growth factors and their release profiles are characterized. This platform is a key step towards engineering smart and closed loop systems for topical applications.Entities:
Keywords: drug delivery; epidermal patches; flexible electronics; thermoresponsive particles; wound dressings
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Year: 2015 PMID： 26501166 DOI： 10.1002/adhm.201500357
Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933