Literature DB >> 26500917

Metastatic Renal Cell Carcinoma: An Unusual Cause of Bleeding Pancreatic Mass.

Smeeta Gajendra1, Ritesh Sachdev2, Ishani Mohapatra3, Ruchika Goel4, Shalini Goel4.   

Abstract

Renal Cell Carcinoma metastasizing to pancreas is uncommon, occurring in 1-2% of cases; lung being the most common site. It is usually asymptomatic, or may present as abdominal pain, weight loss, pancreatitis or gastrointestinal bleeding. Herein, we present a case of 75-year-old male presented as intraabdominal bleeding to the Emergency Department. Contrast enhanced computed tomography with angiography of abdomen showed lobulated soft tissue mass in the uncinate process region, infiltrating into the distal third and proximal fourth part of duodenum. A clinico-radiological diagnosis of carcinoma head of pancreas infiltrating into duodenum was made and the patient underwent Whipple's operation. With past history of nephrectomy 3 years back, microscopy and the immunoprofile; a final diagnosis of clear cell renal cell carcinoma metastasizing to pancreas was given on histopathology. A high index of suspicion is required for patients with a history of RCC and they should be monitored lifelong for early detection of metastases and to improve survival.

Entities:  

Keywords:  Clear cell carcinoma; Immunohistochemistry; Pancreatic metastasis

Year:  2015        PMID: 26500917      PMCID: PMC4606246          DOI: 10.7860/JCDR/2015/14350.6519

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  15 in total

1.  Pancreatic metastases from renal cell carcinoma: the state of the art.

Authors:  Roberto Ballarin; Mario Spaggiari; Nicola Cautero; Nicola De Ruvo; Roberto Montalti; Cristina Longo; Anna Pecchi; Patrizia Giacobazzi; Giuseppina De Marco; Giuseppe D'Amico; Giorgio Enrico Gerunda; Fabrizio Di Benedetto
Journal:  World J Gastroenterol       Date:  2011-11-21       Impact factor: 5.742

2.  Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma.

Authors:  Tarek M Mekhail; Rony M Abou-Jawde; Gabriel Boumerhi; Sareena Malhi; Laura Wood; Paul Elson; Ronald Bukowski
Journal:  J Clin Oncol       Date:  2005-02-01       Impact factor: 44.544

3.  Metastatic tumors in the pancreas in the modern era.

Authors:  Ioannis T Konstantinidis; Abdulmetin Dursun; Hui Zheng; Jennifer A Wargo; Sarah P Thayer; Carlos Fernandez-del Castillo; Andrew L Warshaw; Cristina R Ferrone
Journal:  J Am Coll Surg       Date:  2010-12       Impact factor: 6.113

Review 4.  Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease.

Authors:  Nicolette K Janzen; Hyung L Kim; Robert A Figlin; Arie S Belldegrun
Journal:  Urol Clin North Am       Date:  2003-11       Impact factor: 2.241

5.  Pancreatic resection for metastatic renal cell carcinoma to the pancreas.

Authors:  Kamran M H Karimi; David W McFadden
Journal:  Am Surg       Date:  2007-11       Impact factor: 0.688

Review 6.  Systematic review of pancreatic surgery for metastatic renal cell carcinoma.

Authors:  P J Tanis; N A van der Gaag; O R C Busch; T M van Gulik; D J Gouma
Journal:  Br J Surg       Date:  2009-06       Impact factor: 6.939

Review 7.  Metastases from renal cell carcinoma presenting as gastrointestinal bleeding: two case reports and a review of the literature.

Authors:  Gareth J Sadler; Mark R Anderson; Mark S Moss; Paul G Wilson
Journal:  BMC Gastroenterol       Date:  2007-01-31       Impact factor: 3.067

8.  Metastases to the Pancreas: Computed Tomography Imaging Spectrum and Clinical Features: A Retrospective Study of 18 Patients With 36 Metastases.

Authors:  Hong-Yuan Shi; Xue-Song Zhao; Fei Miao
Journal:  Medicine (Baltimore)       Date:  2015-06       Impact factor: 1.889

9.  Late solitary pancreatic metastasis from renal cell carcinoma: a case report.

Authors:  Anastasios Katsourakis; George Noussios; Iosif Hadjis; Michael Alatsakis; Efthimios Chatzitheoklitos
Journal:  Case Rep Med       Date:  2012-06-26

10.  Surgical excision of duodenal/pancreatic metastatic renal cell carcinoma.

Authors:  Eduardo Espinoza; Ali Hassani; Ulka Vaishampayan; Dongping Shi; J Edson Pontes; Donald W Weaver
Journal:  Front Oncol       Date:  2014-08-14       Impact factor: 6.244

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  8 in total

Review 1.  Isolated pancreatic metastases from renal cell carcinoma: an outcome of a special metastatic pathway or of specific tumor cell selection?

Authors:  Franz Sellner
Journal:  Clin Exp Metastasis       Date:  2018-06-12       Impact factor: 5.150

2.  Surgical management of hepato-pancreatic metastasis from renal cell carcinoma.

Authors:  Nikolaos A Chatzizacharias; Anais Rosich-Medina; Khaled Dajani; Simon Harper; Emmanuel Huguet; Siong S Liau; Raaj K Praseedom; Asif Jah
Journal:  World J Gastrointest Oncol       Date:  2017-02-15

3.  Duodenal Metastases From Renal Cell Carcinoma Presented With Melena: Review and Case Report.

Authors:  Ramesh Omranipour; Habibollah Mahmoud Zadeh; Fershteh Ensani; Samira Yadegari; Seyed Rohollah Miri
Journal:  Iran J Pathol       Date:  2017-07-01

4.  Gallbladder metastasis of renal clear cell carcinoma 15 years after primary cancer excision: a case report.

Authors:  Yasufumi Saito; Hiroshi Okuda; Makoto Yoshida; Seiji Okimasa; Toshikatsu Fukuda; Masatsugu Yano; Makoto Ochi; Yuzo Okamoto; Hirofumi Nakayama; Eiji Ono; Hideki Ohdan
Journal:  J Med Case Rep       Date:  2018-05-31

5.  CT diagnosis for metastasis of clear cell renal cell carcinoma to the pancreas: Three case reports.

Authors:  Qian Yu; Fanggong Kan; Zhoupeng Ma; Tianke Wang; Guansheng Lin; Bingye Chen; Wenliang Zhao
Journal:  Medicine (Baltimore)       Date:  2018-11       Impact factor: 1.817

Review 6.  Observations on Solitary Versus Multiple Isolated Pancreatic Metastases of Renal Cell Carcinoma: Another Indication of a Seed and Soil Mechanism?

Authors:  Franz Sellner
Journal:  Cancers (Basel)       Date:  2019-09-17       Impact factor: 6.639

Review 7.  Isolated Pancreatic Metastases of Renal Cell Carcinoma-A Paradigm of a Seed and Soil Mechanism: A Literature Analysis of 1,034 Observations.

Authors:  Franz Sellner
Journal:  Front Oncol       Date:  2020-05-29       Impact factor: 6.244

Review 8.  Isolated Pancreatic Metastases of Renal Cell Cancer: Genetics and Epigenetics of an Unusual Tumour Entity.

Authors:  Franz Sellner; Sabine Thalhammer; Martin Klimpfinger
Journal:  Cancers (Basel)       Date:  2022-03-17       Impact factor: 6.639

  8 in total

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