Amar Singh Thakur1, Gian Paolo Littarru2, Iwao Funahashi3, Umeshwar Singh Painkara4, Narendra Shriram Dange5, Prabha Chauhan6. 1. Professor & Head, Department of Biochemistry, GMC Jagdalpur(C.G), India . 2. Professor, Department of Biochemistry, Biology and Genetics, Polytechnique University of the Marche , Ancone, Italy . 3. Director, Research, Kaneka Corporation Ltd ., Japan . 4. Dean & Professor, Department of Medicine, Government Medical College , Jagdalpur(CG), India . 5. Associate Professor, Department of Biochemistry, GMC(CG) , India . 6. Associate Professor, Department of Gynecology, GMC(CG) , India .
Abstract
INTRODUCTION: The male sperm counts decline due to environmental factors, such as pesticides, heavy metals and exogenous estrogens causing negative impact on spermatogenesis. The low testosterone levels are associated with lower levels of antioxidants that protect against free radical damage to glands that produce testosterone. The earlier studies showed that the supplementation of vitamins and antioxidants including 10mg Ubiquinol per-day increases in sperm count and motility. MATERIALS AND METHODS: The Ubiquinol is strong antioxidant, hence in view of the above study 150 mg/day Ubiquinol was supplemented to 60 men with age group of 20-40 years. The patients were supplemented for six months, the testosterone level and sperm parameters were analysed before and after supplementation of Ubiquinol every month up to six months. The total sperm count increased by 53% (p<0.05). RESULTS: The total sperm motility was observed 26% (p<0.05) high after supplementations. Out of total motility, the quantity of rapidly motile sperm increased 41% (p<0.05). The number of sluggish motile sperm was decreased approximate 29% (p<0.05). The non motile sperm count was also decreased up to 55% (p<0.05). CONCLUSION: The testosterone level is maintained during the study and morphology of flagella of sperm has improved. The finding suggests that the supplementation of Ubiquinol may be beneficial for oligospermic patients.
INTRODUCTION: The male sperm counts decline due to environmental factors, such as pesticides, heavy metals and exogenous estrogens causing negative impact on spermatogenesis. The low testosterone levels are associated with lower levels of antioxidants that protect against free radical damage to glands that produce testosterone. The earlier studies showed that the supplementation of vitamins and antioxidants including 10mg Ubiquinol per-day increases in sperm count and motility. MATERIALS AND METHODS: The Ubiquinol is strong antioxidant, hence in view of the above study 150 mg/day Ubiquinol was supplemented to 60 men with age group of 20-40 years. The patients were supplemented for six months, the testosterone level and sperm parameters were analysed before and after supplementation of Ubiquinol every month up to six months. The total sperm count increased by 53% (p<0.05). RESULTS: The total sperm motility was observed 26% (p<0.05) high after supplementations. Out of total motility, the quantity of rapidly motile sperm increased 41% (p<0.05). The number of sluggish motile sperm was decreased approximate 29% (p<0.05). The non motile sperm count was also decreased up to 55% (p<0.05). CONCLUSION: The testosterone level is maintained during the study and morphology of flagella of sperm has improved. The finding suggests that the supplementation of Ubiquinol may be beneficial for oligospermic patients.
Entities:
Keywords:
Anitoxidant; Male infertility; Seminal plasma
Authors: G Balercia; A Mancini; F Paggi; L Tiano; A Pontecorvi; M Boscaro; A Lenzi; G P Littarru Journal: J Endocrinol Invest Date: 2009-05-21 Impact factor: 4.256
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