Literature DB >> 2649979

The purine path to chemotherapy.

G B Elion1.   

Abstract

Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirus infections (acyclovir), and for the prevention of organ transplant rejection (azathioprine).

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Year:  1989        PMID： 2649979     DOI： 10.1126/science.2649979

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  144 in total

1.  Structural effect of the anticancer agent 6-thioguanine on duplex DNA.

Authors:  Jen Bohon; Carlos R de los Santos
Journal:  Nucleic Acids Res       Date:  2003-02-15       Impact factor: 16.971

2.  The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition.

Authors:  Ken Okamoto; Koji Matsumoto; Russ Hille; Bryan T Eger; Emil F Pai; Takeshi Nishino
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-17       Impact factor: 11.205

Review 3.  Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy.

Authors:  Murtaza S Nagree; Lucía López-Vásquez; Jeffrey A Medin
Journal:  World J Stem Cells       Date:  2015-12-26       Impact factor: 5.326

4.  NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.

Authors:  Takaya Moriyama; Rina Nishii; Virginia Perez-Andreu; Wenjian Yang; Federico Antillon Klussmann; Xujie Zhao; Ting-Nien Lin; Keito Hoshitsuki; Jacob Nersting; Kentaro Kihira; Ute Hofmann; Yoshihiro Komada; Motohiro Kato; Robert McCorkle; Lie Li; Katsuyoshi Koh; Cesar Rolando Najera; Shirley Kow-Yin Kham; Tomoya Isobe; Zhiwei Chen; Edwynn Kean-Hui Chiew; Deepa Bhojwani; Cynthia Jeffries; Yan Lu; Matthias Schwab; Hiroto Inaba; Ching-Hon Pui; Mary V Relling; Atsushi Manabe; Hiroki Hori; Kjeld Schmiegelow; Allen E J Yeoh; William E Evans; Jun J Yang
Journal:  Nat Genet       Date:  2016-02-15       Impact factor: 38.330

5.  Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine.

Authors:  T Dervieux; Y Médard; V Baudouin; A Maisin; D Zhang; F Broly; C Loirat; E Jacqz-Aigrain
Journal:  Br J Clin Pharmacol       Date:  1999-12       Impact factor: 4.335

6.  Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia.

Authors:  Patchva Dorababu; Narayana Nagesh; Vijay Gandhi Linga; Sadashivudu Gundeti; Vijay Kumar Kutala; Pallu Reddanna; Raghunadharao Digumarti
Journal:  Eur J Clin Pharmacol       Date:  2011-10-19       Impact factor: 2.953

7.  6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.

Authors:  Hongxia Wang; Yinsheng Wang
Journal:  Biochemistry       Date:  2009-03-17       Impact factor: 3.162

8.  6-thioguanine induces mitochondrial dysfunction and oxidative DNA damage in acute lymphoblastic leukemia cells.

Authors:  Fan Zhang; Lijuan Fu; Yinsheng Wang
Journal:  Mol Cell Proteomics       Date:  2013-09-16       Impact factor: 5.911

9.  Freshwater bacteria can methylate selenium through the thiopurine methyltransferase pathway.

Authors:  Lionel Ranjard; Sylvie Nazaret; Benoit Cournoyer
Journal:  Appl Environ Microbiol       Date:  2003-07       Impact factor: 4.792

10.  The long-term risk of continuous immunosuppression using thioguanides in inflammatory bowel disease.

Authors:  Anthony O'Connor; Asghar Qasim; Colm A O'Moráin
Journal:  Ther Adv Chronic Dis       Date:  2010-01       Impact factor: 5.091
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