| Literature DB >> 26498572 |
Anastasiya S Sokolova1, Olga I Yarovaya2, Andrey V Shernyukov3, Yuriy V Gatilov1, Yuliya V Razumova4, Vladimir V Zarubaev5, Tatiana S Tretiak6, Andrey G Pokrovsky4, Oleg I Kiselev6, Nariman F Salakhutdinov1.
Abstract
A new class of compounds featuring a camphor moiety has been discovered that exhibits potent inhibitory activity against influenza A(H1N1)pdm09 and A(H5N1) viruses. The synthesized compounds were characterized by spectroscopic analysis; in addition the structures of compound 2 and 14 were elucidated by the X-ray diffraction technique. Structure-activity relationship studies have been conducted to identify the 1,7,7-trimethylbicyclo[2.2.1]heptanes2-ylidene group as the key functional group responsible for the observed antiviral activity. The most potent antiviral compound is imine 2 with therapeutic index more than 500.Entities:
Keywords: Antiviral; Cage compounds; Camphor derivatives; Influenza
Mesh：
Substances：
Year: 2015 PMID： 26498572 DOI： 10.1016/j.ejmech.2015.10.010
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514