| Literature DB >> 26497834 |
Theresa Dankowski1, Dorothea Buck2, Till F M Andlauer3, Gisela Antony4, Antonios Bayas5, Lukas Bechmann6,7, Achim Berthele2, Thomas Bettecken3, Andrew Chan8, Andre Franke9, Ralf Gold8, Christiane Graetz10, Jürgen Haas11, Michael Hecker12, Stefan Herms13,14,15,16, Carmen Infante-Duarte17, Karl-Heinz Jöckel18, Bernd C Kieseier19, Benjamin Knier2, Matthias Knop20, Tania Kümpfel21, Peter Lichtner22,23, Wolfgang Lieb24, Christina M Lill10,25, Volker Limmroth26, Ralf A Linker27, Verena Loleit2, Sven G Meuth28, Susanne Moebus18, Bertram Müller-Myhsok3, Sandra Nischwitz20, Markus M Nöthen13,14, Friedemann Paul17,29, Michael Pütz30, Tobias Ruck28, Anke Salmen8, Martin Stangel31, Jan-Patrick Stellmann32, Konstantin Strauch33,34, Klarissa H Stürner32, Björn Tackenberg30, Florian Then Bergh35, Hayrettin Tumani36, Melanie Waldenberger37,38, Frank Weber20,39, Heinz Wiendl28, Brigitte Wildemann11, Uwe K Zettl12, Ulf Ziemann40, Frauke Zipp10, Bernhard Hemmer2,41, Andreas Ziegler1,42,43.
Abstract
Genome-wide association studies (GWAS) successfully identified various chromosomal regions to be associated with multiple sclerosis (MS). The primary aim of this study was to replicate reported associations from GWAS using an exome array in a large German study. German MS cases (n = 4,476) and German controls (n = 5,714) were genotyped using the Illumina HumanExome v1-Chip. Genotype calling was performed with the Illumina Genome Studio(TM) Genotyping Module, followed by zCall. Single-nucleotide polymorphisms (SNPs) in seven regions outside the human leukocyte antigen (HLA) region showed genome-wide significant associations with MS (P values < 5 × 10(-8) ). These associations have been reported previously. In addition, SNPs in three previously reported regions outside the HLA region yielded P values < 10(-5) . The effect of nine SNPs in the HLA region remained (P < 10(-5) ) after adjustment for other significant SNPs in the HLA region. All of these findings have been reported before or are driven by known risk loci. In summary, findings from previous GWAS for MS could be successfully replicated. We conclude that the regions identified in previous GWAS are also associated in the German population. This reassures the need for detailed investigations of the functional mechanisms underlying the replicated associations.Entities:
Keywords: ANKRD55 gene; HLA-DPB2 gene; Illumina exome array; MMEL1 gene; genome-wide association study; multiple sclerosis
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Year: 2015 PMID： 26497834 DOI： 10.1002/gepi.21933
Source DB: PubMed Journal: Genet Epidemiol ISSN： 0741-0395 Impact factor: 2.135