Autoimmune disease in pregnancy.

Autoimmunity, whether present in a recognized syndrome such as systemic lupus erythematosus or represented by the production of subclasses of autoantibodies, adversely affects reproduction. While fertility of patients with autoimmune disorders is generally unimpaired, important exceptions exist. Recent data regarding the impact of intercurrent pregnancy upon women with SLE suggest that the overall course of this disorder is not affected. The impact of SLE and related autoimmune phenomena during pregnancy primarily relates to adverse fetal outcome. Pregnancy wastage is excessive, and premature delivery and poor fetal growth are commonly encountered. The occurrence of fetal complications correlates with the level of maternal disease activity and the presence of specific autoantibodies. Management of pregnancy complicated by SLE or the production of autoantibodies associated with poor reproductive outcome should be directed at maintaining maternal disease quiescence. The adverse effect of the maternal disorder on fetal growth and development far outweighs actual or theoretical risks attributable to maternal drug therapy.