Nils Eide1, Øystein Garred2, Klaus Beiske2, Øystein Fodstad3. 1. Eye Department, Oslo University Hospital HF, Oslo, Norway. 2. Division of Pathology, Oslo University Hospital HF, Oslo, Norway. 3. Department of Tumor Biology, Oslo University Hospital HF and University of Oslo, Oslo, Norway.
Abstract
PURPOSE: To report a bilateral uveal melanoma detected in a micrometastasis study. METHOD: Case report. RESULTS: At enucleation of a circumpapillary amelanotic mixed melanoma in a patient with ocular melanocytosis, a pigmented lesion in the other eye was detected, thought to be a naevus. BAP1 was positive showing nuclear staining of the tumour cells. Seven years later the naevus showed growth and development of a retinal detachment. FNAB disclosed monosomy 3 in the spindle tumour cells. CONCLUSION: A case of bilateral melanoma with long-term survival without metastatic diseases is reported. Different gene expressions in the two eyes were revealed. The case is a reminder that follow-up over years is essential in patients with a uveal melanoma, especially with ocular melanocytosis.
PURPOSE: To report a bilateral uveal melanoma detected in a micrometastasis study. METHOD: Case report. RESULTS: At enucleation of a circumpapillary amelanotic mixed melanoma in a patient with ocular melanocytosis, a pigmented lesion in the other eye was detected, thought to be a naevus. BAP1 was positive showing nuclear staining of the tumour cells. Seven years later the naevus showed growth and development of a retinal detachment. FNAB disclosed monosomy 3 in the spindle tumour cells. CONCLUSION: A case of bilateral melanoma with long-term survival without metastatic diseases is reported. Different gene expressions in the two eyes were revealed. The case is a reminder that follow-up over years is essential in patients with a uveal melanoma, especially with ocular melanocytosis.