| Literature DB >> 26496831 |
Xiaofen Yuan1, Xidi Wang2, Kehong Bi3, Guosheng Jiang1.
Abstract
Ecotropic virus integration site-1 (EVI-1) gene, locus on chromosome 3 (3q26.2) in the human genome, was first found in the AKXD strain of mice, in a model of retrovirus-induced acute myeloid leukemia (AML) established twenty years ago. Since then, EVI-1 was regarded as one of the most invasive proto-oncogenes in human leukemia. EVI-1 can encode a unique zinc-finger protein of 145 kDa that can bind with DNA, and its overexpression was closely related to human hemopoietic diseases. Furthermore, accumulating research indicates that EVI-1 is involved in the differentiation, apoptosis and proliferation of leukemia cells. The present review focuses on the biochemical properties of EVI-1 which plays a role in myeloid malignancies.Entities:
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Year: 2015 PMID： 26496831 DOI： 10.3892/ijo.2015.3207
Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650