Literature DB >> 26496682

Nuclear Pore Complex: From Structural View to Chemical Tools.

Richard W Wong1.   

Abstract

Nuclear pore complexes (NPCs) are the macromolecular turnstiles between the cytoplasm and the nucleus that control the trafficking of proteins, RNAs and viruses. The giant NPC structures are extremely complex. Here, I highlight several recent findings on NPC architectures, and briefly discuss how chemical biologists might use this information to design synthetic devices and improve strategies for nuclear drug delivery.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Year:  2015        PMID： 26496682     DOI： 10.1016/j.chembiol.2015.10.001

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  6 in total

1.  ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation.

Authors:  Masaharu Hazawa; De-Chen Lin; Akiko Kobayashi; Yan-Yi Jiang; Liang Xu; Firli Rahmah Primula Dewi; Mahmoud Shaaban Mohamed; Mitsutoshi Nakada; Makiko Meguro-Horike; Shin-Ichi Horike; H Phillip Koeffler; Richard W Wong
Journal:  EMBO Rep       Date:  2017-12-07       Impact factor: 8.807

2.  Colorectal cancer cells require glycogen synthase kinase-3β for sustaining mitosis via translocated promoter region (TPR)-dynein interaction.

Authors:  Firli R P Dewi; Takahiro Domoto; Masaharu Hazawa; Akiko Kobayashi; Takayuki Douwaki; Toshinari Minamoto; Richard W Wong
Journal:  Oncotarget       Date:  2018-01-30

3.  Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth.

Authors:  Hiroya Kondo; Kenji Mishiro; Yuki Iwashima; Yujia Qiu; Akiko Kobayashi; Keesiang Lim; Takahiro Domoto; Toshinari Minamoto; Kazuma Ogawa; Munetaka Kunishima; Masaharu Hazawa; Richard W Wong
Journal:  Cells       Date:  2022-01-18       Impact factor: 6.600

4.  Characterization of Two Monoclonal Antibodies That Recognize Linker Region and Carboxyl Terminal Domain of Coronavirus Nucleocapsid Protein.

Authors:  Xin Zhang; Xin Zhao; Hui Dong; Yunnuan Zhu; Hongyan Shi; Jianfei Chen; Da Shi; Li Feng
Journal:  PLoS One       Date:  2016-09-30       Impact factor: 3.240

5.  Nucleoporin Nup58 localizes to centrosomes and mid-bodies during mitosis.

Authors:  Masaharu Hazawa; Kee Siang Lim; Firli R P Dewi; Akiko Kobayashi; Richard W Wong
Journal:  Cell Div       Date:  2019-08-03       Impact factor: 5.130

6.  Disease-specific alteration of karyopherin-α subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma.

Authors:  Masaharu Hazawa; Kie Sakai; Akiko Kobayashi; Hironori Yoshino; Yoshihiro Iga; Yuki Iwashima; Kee Sing Lim; Dominic Chih-Cheng Voon; Yan-Yi Jiang; Shin-Ichi Horike; De-Chen Lin; Richard W Wong
Journal:  Oncogene       Date:  2019-12-10       Impact factor: 9.867
  6 in total

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