J Gaultney1, M Benucci2, S Iannazzo3, C Nappi4, K Sion1, F J Sabater5. 1. a Mapi Group , Houten , Netherlands. 2. b Ospedale S.Giovanni di Dio Firenze , Florence , Italy. 3. c SIHS Health Economics Consulting , Turin , Italy. 4. d Bristol-Myers Squibb , Rome , Italy. 5. e Bristol-Myers Squibb , Madrid , Spain.
Abstract
INTRODUCTION: Rheumatoid arthritis (RA) is a chronic, inflammatory disorder leading to disability and reduced quality of life. Effective treatment is a significant economic burden on the Italian healthcare system. Economic models in RA are commonly based on indirect treatment comparisons. METHODS: This study assessed the cost-effectiveness of abatacept relative to adalimumab for RA in Italy based on a head-to-head trial by means of a cost-consequence analysis. RESULTS: Health benefits based on the most stringent efficacy criteria were in favor of abatacept compared to adalimumab. Rates for more costly adverse events were higher for adalimumab compared to abatacept, which was reflected in the lower costs for abatacept (-€237,246 or -€237per patient). CONCLUSION: The health economic value of abatacept compared with adalimumab from the perspective of the Italian NHS depends on the choice of health outcome. Health gains with abatacept were generally based on more stringent criteria and lower total costs.
RCT Entities:
INTRODUCTION:Rheumatoid arthritis (RA) is a chronic, inflammatory disorder leading to disability and reduced quality of life. Effective treatment is a significant economic burden on the Italian healthcare system. Economic models in RA are commonly based on indirect treatment comparisons. METHODS: This study assessed the cost-effectiveness of abatacept relative to adalimumab for RA in Italy based on a head-to-head trial by means of a cost-consequence analysis. RESULTS: Health benefits based on the most stringent efficacy criteria were in favor of abatacept compared to adalimumab. Rates for more costly adverse events were higher for adalimumab compared to abatacept, which was reflected in the lower costs for abatacept (-€237,246 or -€237per patient). CONCLUSION: The health economic value of abatacept compared with adalimumab from the perspective of the Italian NHS depends on the choice of health outcome. Health gains with abatacept were generally based on more stringent criteria and lower total costs.
Authors: Laure Weijers; Christoph Baerwald; Francesco S Mennini; José M Rodríguez-Heredia; Martin J Bergman; Denis Choquette; Kirsten H Herrmann; Giulia Attinà; Carmela Nappi; Silvia Jimenez Merino; Chad Patel; Mondher Mtibaa; Jason Foo Journal: Rheumatol Int Date: 2017-05-30 Impact factor: 2.631