| Literature DB >> 26495885 |
Sen Liu1,2, Nan Wu1,2, Jiaqi Liu1, Hao Liu3, Xinlin Su1, Zhenlei Liu1, Yuzhi Zuo1, Weisheng Chen1, Gang Liu1, Yixin Chen1, Yue Ming4, Tangmi Yuan1, Xiao Li1, Jun Chen1, Zenan Xia1, Shengru Wang1, Jia Chen1, Tao Liu5, Xu Yang1, Yufen Ma1, Jianguo Zhang1, Jianxiong Shen1, Shugang Li1, Yipeng Wang1, Hong Zhao1, Keyi Yu1, Yu Zhao1, Shishu Huang6, Xisheng Weng1, Guixing Qiu1,2, Chao Wan7,8, Guangqian Zhou5, Zhihong Wu2,9.
Abstract
Low back pain (LBP) is a common health problem and many LBP are caused by lumbar disc degeneration (LDD). ADAMTS-4 (a disintegrin and metalloprotease with thrombospondin motifs-4), also known as aggrecanse-1, plays a core role in degeneration of extracellular matrix in LDD. To investigate the association between ADAMTS-4 genetic polymorphism and LDD, we genotyped SNPs in and around ADAMTS-4. We recruited 482 sporadic cases of LDD and 496 healthy controls from Chinese Han population. Five SNPs were selected and phenotyped by the Sequenom MassARRAY system. Allelic, genotypic, and haplotypic association was performed. Rs4233367 (c.1877 C>T), which located in exon of ADAMTS-4 showed significant association with LDD. The T allele conferred a lower risk of LDD with an OR of 0.69 and TT genotype is at nearly one-fifth of the risk compared to CC genotype. Other tested SNPs didn't show significant difference between the case and control groups. The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration.Entities:
Keywords: a disintegrin and metalloprotease with thrombospondin motifs-4 (ADAMTS-4); lumbar disc degeneration (LDD); single nucleotide polymorphism (SNP)
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Year: 2015 PMID： 26495885 DOI： 10.1002/jor.23081
Source DB: PubMed Journal: J Orthop Res ISSN： 0736-0266 Impact factor: 3.494