Literature DB >> 2649494

In vitro proteolytic cleavage of the Escherichia coli Ada protein by the ompT gene product.

B Sedgwick1.   

Abstract

Down regulation of the adaptive response to alkylation damage in Escherichia coli has been proposed to occur by proteolytic cleavage of the regulatory Ada protein. In this paper, it is shown that proteolysis of the Ada protein as observed in cell extracts is caused by the ompT gene product. This protease, however, was not involved in switching off the adaptive response in vivo.

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Year:  1989        PMID： 2649494      PMCID： PMC209889          DOI： 10.1128/jb.171.4.2249-2251.1989

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  20 in total

1.  Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli.

Authors:  T V McCarthy; T Lindahl
Journal:  Nucleic Acids Res       Date:  1985-04-25       Impact factor: 16.971

2.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

3.  A new pathway for DNA repair in Escherichia coli.

Authors:  L Samson; J Cairns
Journal:  Nature       Date:  1977-05-19       Impact factor: 49.962

4.  Alteration of the carboxyl-terminal domain of Ada protein influences its inducibility, specificity, and strength as a transcriptional activator.

Authors:  D E Shevell; P K LeMotte; G C Walker
Journal:  J Bacteriol       Date:  1988-11       Impact factor: 3.490

5.  omp T: Escherichia coli K-12 structural gene for protein a (3b).

Authors:  K R Rupprecht; G Gordon; M Lundrigan; R C Gayda; A Markovitz; C Earhart
Journal:  J Bacteriol       Date:  1983-02       Impact factor: 3.490

Review 6.  Microbial envelope proteins related to iron.

Authors:  J B Neilands
Journal:  Annu Rev Microbiol       Date:  1982       Impact factor: 15.500

7.  Sequence of the regulatory region of omp T, the gene specifying major outer membrane protein a (3b) of Escherichia coli K-12: implications for regulation and processing.

Authors:  G Gordon; R C Gayda; A Markovitz
Journal:  Mol Gen Genet       Date:  1984

8.  Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

Authors:  B Demple; A Jacobsson; M Olsson; P Robins; T Lindahl
Journal:  J Biol Chem       Date:  1982-11-25       Impact factor: 5.157

9.  Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

Authors:  B Demple; B Sedgwick; P Robins; N Totty; M D Waterfield; T Lindahl
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

10.  Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

Authors:  I Teo; B Sedgwick; B Demple; B Li; T Lindahl
Journal:  EMBO J       Date:  1984-09       Impact factor: 11.598
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  13 in total

1.  Colicin cleavage by OmpT protease during both entry into and release from Escherichia coli cells.

Authors:  D Cavard; C Lazdunski
Journal:  J Bacteriol       Date:  1990-02       Impact factor: 3.490

2.  In vivo degradation of secreted fusion proteins by the Escherichia coli outer membrane protease OmpT.

Authors:  F Baneyx; G Georgiou
Journal:  J Bacteriol       Date:  1990-01       Impact factor: 3.490

3.  Determination of the native form of FadD, the Escherichia coli fatty acyl-CoA synthetase, and characterization of limited proteolysis by outer membrane protease OmpT.

Authors:  J H Yoo; O H Cheng; G E Gerber
Journal:  Biochem J       Date:  2001-12-15       Impact factor: 3.857

4.  Requirement for two conserved cysteine residues in the Ada protein of Escherichia coli for transactivation of the ada promoter.

Authors:  A Taketomi; Y Nakabeppu; K Ihara; D J Hart; M Furuichi; M Sekiguchi
Journal:  Mol Gen Genet       Date:  1996-03-20

5.  Processing by OmpT of fusion proteins carrying the HlyA transport signal during secretion by the Escherichia coli hemolysin transport system.

Authors:  C Hanke; J Hess; G Schumacher; W Goebel
Journal:  Mol Gen Genet       Date:  1992-05

6.  Induction of the alkA gene of Escherichia coli in gram-negative bacteria.

Authors:  A R Fernandez de Henestrosa; J Barbé
Journal:  J Bacteriol       Date:  1991-12       Impact factor: 3.490

7.  The Ada protein acts as both a positive and a negative modulator of Escherichia coli's response to methylating agents.

Authors:  B M Saget; G C Walker
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-11       Impact factor: 11.205

Review 8.  Proteases and protein degradation in Escherichia coli.

Authors:  M R Maurizi
Journal:  Experientia       Date:  1992-02-15

9.  Alteration of lysine 178 in the hinge region of the Escherichia coli ada protein interferes with activation of ada, but not alkA, transcription.

Authors:  B M Saget; D E Shevell; G C Walker
Journal:  J Bacteriol       Date:  1995-03       Impact factor: 3.490

10.  Improving health from the inside: Use of engineered intestinal microorganisms as in situ cytokine delivery system.

Authors:  Christoph Pöhlmann; Mandy Thomas; Sarah Förster; Manuela Brandt; Maike Hartmann; André Bleich; Florian Gunzer
Journal:  Bioengineered       Date:  2012-10-30       Impact factor: 3.269
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