Literature DB >> 26494872

Amygdala response to self-critical stimuli and symptom improvement in psychotherapy for depression.

Nadja Doerig1, Tobias Krieger2, David Altenstein2, Yolanda Schlumpf2, Simona Spinelli2, Jakub Späti2, Janis Brakowski2, Boris B Quednow2, Erich Seifritz2, Martin Grosse Holtforth2.   

Abstract

BACKGROUND: Cognitive-behavioural therapy is efficacious in the treatment of major depressive disorder but response rates are still far from satisfactory. AIMS: To better understand brain responses to individualised emotional stimuli and their association with outcome, to enhance treatment.
METHOD: Functional magnetic resonance imaging data were collected prior to individual psychotherapy. Differences in brain activity during passive viewing of individualised self-critical material in 23 unmedicated out-patients with depression and 28 healthy controls were assessed. The associations between brain activity, cognitive and emotional change, and outcome were analysed in 21 patients.
RESULTS: Patients showed enhanced activity in the amygdala and ventral striatum compared with the control group. Non-response to therapy was associated with enhanced activity in the right amygdala compared with those who responded, and activity in this region was negatively associated with outcome. Emotional but not cognitive changes mediated this association.
CONCLUSIONS: Amygdala hyperactivity may lessen symptom improvement in psychotherapy for depression through attenuating emotional skill acquisition. © The Royal College of Psychiatrists 2016.

Entities:  

Mesh:

Year:  2015        PMID: 26494872     DOI: 10.1192/bjp.bp.114.149971

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN: 0007-1250            Impact factor:   9.319


  5 in total

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Journal:  Neural Plast       Date:  2017-01-26       Impact factor: 3.599

2.  The role of microbiota and inflammation in self-judgement and empathy: implications for understanding the brain-gut-microbiome axis in depression.

Authors:  N Heym; B C Heasman; K Hunter; S R Blanco; G Y Wang; R Siegert; A Cleare; G R Gibson; V Kumari; A L Sumich
Journal:  Psychopharmacology (Berl)       Date:  2019-04-07       Impact factor: 4.530

3.  Structural and Functional Neural Correlates of Treatment Response for Interpersonal Psychotherapy for Depressed Adolescents.

Authors:  Bonnie Klimes-Dougan; Zeynep Başgöze; Bryon Mueller; Andrea Wiglesworth; Kathrine A Carosella; Melinda Westlund Schreiner; Ana Bortnova; Kristina Reigstad; Kathryn R Cullen; Meredith Gunlicks-Stoessel
Journal:  J Clin Med       Date:  2022-03-28       Impact factor: 4.241

4.  An ecological animal model of subthreshold depression in adolescence: behavioral and resting state 18F-FDG PET imaging characterization.

Authors:  Georgine Accrombessi; Laurent Galineau; Clovis Tauber; Sophie Serrière; Esteban Moyer; Bruno Brizard; Anne-Marie Le Guisquet; Alexandre Surget; Catherine Belzung
Journal:  Transl Psychiatry       Date:  2022-09-01       Impact factor: 7.989

5.  Pathways to Neuroprediction: Opportunities and challenges to prediction of treatment response in depression.

Authors:  Scott A Langenecker; Natania A Crane; Lisanne M Jenkins; K Luan Phan; Heide Klumpp
Journal:  Curr Behav Neurosci Rep       Date:  2018-01-24
  5 in total

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