| Literature DB >> 26493997 |
Wenjian Yao1, Yu Bai2, Yan Li3, Ling Guo1, Ping Zeng3, Yonglian Wang1, Bo Qi1, Shangguo Liu1, Xiuguang Qin1, Yongzhen Li2, Baosheng Zhao4.
Abstract
The aim of this study is to investigate whether metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) can be used as a potential therapy target for human esophageal squamous cell carcinoma. MALAT-1 expression levels were detected in 137 paired EC samples and adjacent nonneoplastic tissues. Human esophageal carcinoma cell lines EC9706 and KYSE150 were transfected with MALAT-1 small interference RNA. Cell proliferation, migration/invasion ability, cell cycle, and apoptosis were assessed. MALAT-1 expressed higher levels in esophageal cancer tissues when compared with paired adjacent normal tissues. This high expression was associated with a decreased survival rate. MALAT-1 knockdown induced a decrease in proliferation-enhanced apoptosis, inhibited migration/invasion, and reduced colony formation and led to cell cycle arrest at the G2/M phase. These data indicates that MALAT-1 could be exploited for therapeutic benefit.Entities:
Keywords: Esophageal carcinoma; Long noncoding RNA; Metastasis-associated lung adenocarcinoma transcript 1; Small RNA interference
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Year: 2015 PMID： 26493997 DOI： 10.1007/s13277-015-4223-3
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283