Literature DB >> 26493387

BCOR internal tandem duplication and YWHAE-NUTM2B/E fusion are mutually exclusive events in clear cell sarcoma of the kidney.

Jenny Karlsson1, Anders Valind1, David Gisselsson1.   

Abstract

Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal tumor. Two recurrent genetic aberrations have been described in CCSK. One is a fusion of YWHAE and NUTM2B/E, the other is an internal tandem duplication (ITD) in the BCOR gene. Here it is shown that YWHAE-NUTM2B/E fusion and the BCOR ITD are mutually exclusive events and activated different downstream signaling systems. This has important diagnostic implications and opens up for further mechanistic studies of CCSK pathogenesis.
© 2015 Wiley Periodicals, Inc.

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Year:  2015        PMID： 26493387     DOI： 10.1002/gcc.22316

Source DB:  PubMed          Journal:  Genes Chromosomes Cancer        ISSN： 1045-2257            Impact factor:   5.006


  18 in total

1.  Novel High-grade Endometrial Stromal Sarcoma: A Morphologic Mimicker of Myxoid Leiomyosarcoma.

Authors:  Lien N Hoang; Amandeep Aneja; Niamh Conlon; Deborah F Delair; Sumit Middha; Ryma Benayed; Martee L Hensley; Kay J Park; Travis J Hollmann; Meera R Hameed; Cristina R Antonescu; Robert A Soslow; Sarah Chiang
Journal:  Am J Surg Pathol       Date:  2017-01       Impact factor: 6.394

2.  BCOR is a robust diagnostic immunohistochemical marker of genetically diverse high-grade endometrial stromal sarcoma, including tumors exhibiting variant morphology.

Authors:  Sarah Chiang; Cheng-Han Lee; Colin J R Stewart; Esther Oliva; Lien N Hoang; Rola H Ali; Martee L Hensley; Javier A Arias-Stella; Denise Frosina; Achim A Jungbluth; Ryma Benayed; Marc Ladanyi; Meera Hameed; Lu Wang; Yu-Chien Kao; Cristina R Antonescu; Robert A Soslow
Journal:  Mod Pathol       Date:  2017-06-16       Impact factor: 7.842

3.  BCOR-CCNB3 fusion and BCOR internal tandem duplication in undifferentiated round cell sarcoma: a pathologic and molecular study of 5 cases.

Authors:  Yang Yang; Huijuan Shi; Jiaxin Zheng; Huabin Gao; Tiantian Zhen; Fenfen Zhang; Anjia Han
Journal:  Am J Transl Res       Date:  2019-09-15       Impact factor: 4.060

4.  Primary Renal Sarcomas With BCOR-CCNB3 Gene Fusion: A Report of 2 Cases Showing Histologic Overlap With Clear Cell Sarcoma of Kidney, Suggesting Further Link Between BCOR-related Sarcomas of the Kidney and Soft Tissues.

Authors:  Pedram Argani; Yu-Chien Kao; Lei Zhang; Carlos Bacchi; Andres Matoso; Rita Alaggio; Jonathan I Epstein; Cristina R Antonescu
Journal:  Am J Surg Pathol       Date:  2017-12       Impact factor: 6.394

5.  Recurrent BCOR internal tandem duplication and BCOR or BCL6 expression distinguish primitive myxoid mesenchymal tumor of infancy from congenital infantile fibrosarcoma.

Authors:  Teresa Santiago; Michael R Clay; Sariah J Allen; Brent A Orr
Journal:  Mod Pathol       Date:  2017-03-03       Impact factor: 7.842

6.  BCOR Overexpression in Renal Malignant Solitary Fibrous Tumors: A Close Mimic of Clear Cell Sarcoma of Kidney.

Authors:  Pedram Argani; Yu-Chien Kao; Lei Zhang; Yun-Shao Sung; Rita Alaggio; David Swanson; Andres Matoso; Brendan C Dickson; Cristina R Antonescu
Journal:  Am J Surg Pathol       Date:  2019-06       Impact factor: 6.394

7.  Proteomic approaches for cancer epigenetics research.

Authors:  Dylan M Marchione; Benjamin A Garcia; John Wojcik
Journal:  Expert Rev Proteomics       Date:  2018-11-27       Impact factor: 3.940

8.  Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney.

Authors:  Yu-Chien Kao; Yun-Shao Sung; Lei Zhang; Shih-Chiang Huang; Pedram Argani; Catherine T Chung; Nicole S Graf; Dale C Wright; Stewart J Kellie; Narasimhan P Agaram; Kathrin Ludwig; Angelica Zin; Rita Alaggio; Cristina R Antonescu
Journal:  Am J Surg Pathol       Date:  2016-08       Impact factor: 6.394

Review 9.  Position paper: Rationale for the treatment of children with CCSK in the UMBRELLA SIOP-RTSG 2016 protocol.

Authors:  Saskia L Gooskens; Norbert Graf; Rhoikos Furtwängler; Filippo Spreafico; Christophe Bergeron; Gema L Ramírez-Villar; Jan Godzinski; Christian Rübe; Geert O Janssens; Gordan M Vujanic; Ivo Leuschner; Aurore Coulomb-L'Hermine; Anne M Smets; Beatriz de Camargo; Sara Stoneham; Harm van Tinteren; Kathy Pritchard-Jones; Marry M van den Heuvel-Eibrink
Journal:  Nat Rev Urol       Date:  2018-02-27       Impact factor: 14.432

10.  ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity.

Authors:  Natasha Lewis; Robert A Soslow; Deborah F Delair; Kay J Park; Rajmohan Murali; Travis J Hollmann; Ben Davidson; Francesca Micci; Ioannis Panagopoulos; Lien N Hoang; Javier A Arias-Stella; Esther Oliva; Robert H Young; Martee L Hensley; Mario M Leitao; Meera Hameed; Ryma Benayed; Marc Ladanyi; Denise Frosina; Achim A Jungbluth; Cristina R Antonescu; Sarah Chiang
Journal:  Mod Pathol       Date:  2017-12-01       Impact factor: 7.842
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