J Bassols1,2, J M Martínez-Calcerrada3,4, A Prats-Puig3,5, G Carreras-Badosa3,6, F Díaz-Roldán3,6, I Osiniri7, E Riera-Pérez7, F de Zegher8, L Ibáñez9,10, A López-Bermejo3,6,11. 1. Pediatrics Research Group, Girona Institute for Biomedical Research, Girona, Spain. jbassols@idibgi.org. 2. Pediatrics, Dr. JosepTrueta Hospital, Girona, Spain. jbassols@idibgi.org. 3. Pediatrics Research Group, Girona Institute for Biomedical Research, Girona, Spain. 4. Forensic Medicine, Institute of Legal Medicine of Catalonia, Girona, Spain. 5. Department of Physical Therapy, EUSES University School, University of Girona, Girona, Spain. 6. Pediatrics, Dr. JosepTrueta Hospital, Girona, Spain. 7. Pediatrics, Salut Empordà Foundation, Figueres, Spain. 8. Department of Development & Regeneration, University of Leuven, Leuven, Belgium. 9. Pediatric Endocrinology, Sant Joan de Déu Children's Hospital, Barcelona, Spain. 10. CIBERDEM (Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders), ISCIII, Madrid, Spain. 11. TransLab Research Group, Department of Medical Sciences, Faculty of Medicine (A.L-B), University of Girona, Girona, Spain.
Abstract
BACKGROUND: Increased uric acid is an independent biomarker for cardiovascular disease in obese adolescents and adults. OBJECTIVE: We investigated whether uric acid relates to carotid intima-media thickness (cIMT) in prepubertal children, and whether body mass index (BMI) and preperitoneal fat modulate this association. METHODS: 359 asymptomatic prepubertal Caucasian children were stratified according to BMI categories (171 with BMI-SDS < 0; 188 with BMI-SDS ≥ 0) and according to preperitoneal fat levels (180 with preperitoneal fat <50th centile; 179 with preperitoneal fat >50th centile). Uric acid levels, insulin resistance (homeostasis model assessment insulin resistance; HOMA-IR), C-reactive protein (CRP), triacylglycerol (TG), systolic blood pressure (SBP), abdominal fat and cIMT (both by ultrasound) were assessed. RESULTS: Uric acid was associated with several cardiovascular risk factors, namely higher HOMA-IR, CRP, TG, BMI, waist, SBP, preperitoneal fat and cIMT (all P < 0.001 to P < 0.0001). Significant BMI and preperitoneal fat interactions were documented in the relationship between uric acid and cIMT (both P < 0.05), as uric acid was preferentially related to cIMT in heavier children (β = 0.247, P < 0.001, r(2) = 9.1%) and in children with more preperitoneal fat (β = 0.263, P < 0.0001, r(2) = 11.9%). CONCLUSIONS: Serum uric acid is associated with cIMT in asymptomatic prepubertal children. Both higher BMI and preperitoneal fat aggravate the potential risk of atherosclerotic disease imposed by higher concentrations of uric acid.
BACKGROUND: Increased uric acid is an independent biomarker for cardiovascular disease in obese adolescents and adults. OBJECTIVE: We investigated whether uric acid relates to carotid intima-media thickness (cIMT) in prepubertal children, and whether body mass index (BMI) and preperitoneal fat modulate this association. METHODS: 359 asymptomatic prepubertal Caucasian children were stratified according to BMI categories (171 with BMI-SDS < 0; 188 with BMI-SDS ≥ 0) and according to preperitoneal fat levels (180 with preperitoneal fat <50th centile; 179 with preperitoneal fat >50th centile). Uric acid levels, insulin resistance (homeostasis model assessment insulin resistance; HOMA-IR), C-reactive protein (CRP), triacylglycerol (TG), systolic blood pressure (SBP), abdominal fat and cIMT (both by ultrasound) were assessed. RESULTS:Uric acid was associated with several cardiovascular risk factors, namely higher HOMA-IR, CRP, TG, BMI, waist, SBP, preperitoneal fat and cIMT (all P < 0.001 to P < 0.0001). Significant BMI and preperitoneal fat interactions were documented in the relationship between uric acid and cIMT (both P < 0.05), as uric acid was preferentially related to cIMT in heavier children (β = 0.247, P < 0.001, r(2) = 9.1%) and in children with more preperitoneal fat (β = 0.263, P < 0.0001, r(2) = 11.9%). CONCLUSIONS: Serum uric acid is associated with cIMT in asymptomatic prepubertal children. Both higher BMI and preperitoneal fat aggravate the potential risk of atherosclerotic disease imposed by higher concentrations of uric acid.
Authors: Emily S Andrews; Loni Perrenoud; Kristen L Nowak; Zhiying You; Andreas Pasch; Michel Chonchol; Jessica Kendrick; Diana Jalal Journal: PLoS One Date: 2018-10-24 Impact factor: 3.240
Authors: Lide Arenaza; Victoria Muñoz-Hernández; María Medrano; Maddi Oses; Maria Amasene; Elisa Merchán-Ramírez; Cristina Cadenas-Sanchez; Francisco B Ortega; Jonatan R Ruiz; Idoia Labayen Journal: Nutrients Date: 2018-08-10 Impact factor: 5.717