Literature DB >> 2649188

Identification of the target platelet glycoprotein in autoimmune thrombocytopenia occurring after allogeneic bone marrow transplantation.

H Benda1, S Panzer, V Kiefel, C Mannhalter, W Hinterberger, K Lechner, C Mueller-Eckhardt.   

Abstract

We report the case of a patient who developed autoimmune thrombocytopenia after allogeneic bone marrow transplantation from her HLA-identical sister. An IgG autoantibody was detected that bound to the platelet glycoprotein IIb/IIIa and to the HLA class I proteins. Immunoprecipitation studies with radiolabeled platelets revealed additional antibody binding sites on proteins of 214 kDa molecular weight under nonreduced conditions and 65 and 56 kDa molecular weight under reduced conditions.

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Year:  1989        PMID： 2649188     DOI： 10.1007/bf00320436

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  18 in total

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Authors:  F M Brodsky; P Parham; C J Barnstable; M J Crumpton; W F Bodmer
Journal:  Immunol Rev       Date:  1979       Impact factor: 12.988

2.  Autoantibodies against platelet GPIIb/IIIa in chronic ITP react with different epitopes.

Authors:  T Tsubakio; P Tani; V L Woods; R McMillan
Journal:  Br J Haematol       Date:  1987-11       Impact factor: 6.998

3.  Platelet surface antigens: analysis by monoclonal antibodies. I. Antibodies. I. Immunological and biochemical studies.

Authors:  S Santoso; J Lohmeyer; H Rennich; K J Clemetson; C Mueller-Eckhardt
Journal:  Blut       Date:  1984-03

Review 4.  Autoimmune platelet destruction: idiopathic thrombocytopenic purpura.

Authors:  J G Kelton; S Gibbons
Journal:  Semin Thromb Hemost       Date:  1982-04       Impact factor: 4.180

5.  Specificity of autoantibodies in autoimmune thrombocytopenia.

Authors:  E F van Leeuwen; J T van der Ven; C P Engelfriet; A E von dem Borne
Journal:  Blood       Date:  1982-01       Impact factor: 22.113

6.  Immunochemical characterization of platelet-specific alloantigens.

Authors:  A Mulder; E F van Leeuwen; G J Veenboer; P A Tetteroo; A E von dem Borne
Journal:  Scand J Haematol       Date:  1984-09

7.  Platelet-associated and plasma anti-glycoprotein autoantibodies in chronic ITP.

Authors:  R McMillan; P Tani; F Millard; P Berchtold; L Renshaw; V L Woods
Journal:  Blood       Date:  1987-10       Impact factor: 22.113

8.  Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia.

Authors:  R Storb; H J Deeg; J Whitehead; F Appelbaum; P Beatty; W Bensinger; C D Buckner; R Clift; K Doney; V Farewell
Journal:  N Engl J Med       Date:  1986-03-20       Impact factor: 91.245

9.  Platelet- and granulocyte-specific antibodies after allogeneic and autologous bone marrow grafts.

Authors:  R M Minchinton; A H Waters; J S Malpas; I Starke; J R Kendra; A J Barrett
Journal:  Vox Sang       Date:  1984       Impact factor: 2.144

10.  Platelet-associated immunoglobulins IgG, IgM, IgA and complement C3 in immune and nonimmune thrombocytopenic disorders.

Authors:  S Panzer; S Szamait; R H Bödeker; O A Haas; A Haubenstock; C Mueller-Eckhardt
Journal:  Am J Hematol       Date:  1986-10       Impact factor: 10.047
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