Literature DB >> 26491179

First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States.

Nathan P Wiederhold1, Veronica Garcia Gil2, Felipe Gutierrez3, Jonathan R Lindner4, Mohammad T Albataineh4, Dora I McCarthy4, Carmita Sanders4, Hongxin Fan4, Annette W Fothergill4, Deanna A Sutton4.   

Abstract

Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur in patients without previous azole exposure have been reported in Europe, Asia, the Middle East, Africa, and Australia. Here, we report the detection of both the TR34 L98H and TR46 Y121F T289A mutations in confirmed A. fumigatus isolates collected in institutions in the United States. These mutations, other mutations known to cause azole resistance, and azole MICs are reported here.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26491179      PMCID： PMC4702720          DOI： 10.1128/JCM.02478-15

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  34 in total

Review 1.  The role of azoles in the management of azole-resistant aspergillosis: from the bench to the bedside.

Authors:  Seyedmojtaba Seyedmousavi; Johan W Mouton; Willem J G Melchers; Roger J M Brüggemann; Paul E Verweij
Journal:  Drug Resist Updat       Date:  2014-07-05       Impact factor: 18.500

2.  Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species.

Authors:  E Mellado; T M Diaz-Guerra; M Cuenca-Estrella; J L Rodriguez-Tudela
Journal:  J Clin Microbiol       Date:  2001-07       Impact factor: 5.948

3.  Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene.

Authors:  Shawn R Lockhart; João P Frade; Kizee A Etienne; Michael A Pfaller; Daniel J Diekema; S Arunmozhi Balajee
Journal:  Antimicrob Agents Chemother       Date:  2011-06-20       Impact factor: 5.191

4.  Development of novel PCR assays to detect azole resistance-mediating mutations of the Aspergillus fumigatus cyp51A gene in primary clinical samples from neutropenic patients.

Authors:  Birgit Spiess; Wolfgang Seifarth; Natalia Merker; Susan J Howard; Mark Reinwald; Anne Dietz; Wolf-Karsten Hofmann; Dieter Buchheidt
Journal:  Antimicrob Agents Chemother       Date:  2012-04-23       Impact factor: 5.191

5.  The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus.

Authors:  Marcin G Fraczek; Michael Bromley; Ahmed Buied; Caroline B Moore; Ranjith Rajendran; Riina Rautemaa; Gordon Ramage; David W Denning; Paul Bowyer
Journal:  J Antimicrob Chemother       Date:  2013-04-10       Impact factor: 5.790

6.  Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults.

Authors:  David W Denning; Alex Pleuvry; Donald C Cole
Journal:  Med Mycol       Date:  2012-12-04       Impact factor: 4.076

7.  Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry.

Authors:  D Neofytos; D Horn; E Anaissie; W Steinbach; A Olyaei; J Fishman; M Pfaller; C Chang; K Webster; K Marr
Journal:  Clin Infect Dis       Date:  2009-02-01       Impact factor: 9.079

8.  Passive surveillance for azole-resistant Aspergillus fumigatus, United States, 2011-2013.

Authors:  Cau D Pham; Errol Reiss; Ferry Hagen; Jacques F Meis; Shawn R Lockhart
Journal:  Emerg Infect Dis       Date:  2014-09       Impact factor: 6.883

9.  Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure.

Authors:  Susan J Howard; Dasa Cerar; Michael J Anderson; Ahmed Albarrag; Matthew C Fisher; Alessandro C Pasqualotto; Michel Laverdiere; Maiken C Arendrup; David S Perlin; David W Denning
Journal:  Emerg Infect Dis       Date:  2009-07       Impact factor: 6.883

10.  Aspergillus species identification in the clinical setting.

Authors:  S A Balajee; J Houbraken; P E Verweij; S-B Hong; T Yaghuchi; J Varga; R A Samson
Journal:  Stud Mycol       Date:  2007       Impact factor: 16.097
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  75 in total

1.  In vivo veritas: Aspergillus fumigatus proliferation and pathogenesis--conditionally speaking.

Authors:  Robert A Cramer
Journal:  Virulence       Date:  2016       Impact factor: 5.882

2.  Epidemiology and Molecular Characterizations of Azole Resistance in Clinical and Environmental Aspergillus fumigatus Isolates from China.

Authors:  Yong Chen; Zhongyi Lu; Jingjun Zhao; Ziying Zou; Yanwen Gong; Fen Qu; Zhiyao Bao; Guangbin Qiu; Mingsheng Song; Qing Zhang; Lin Liu; Mandong Hu; Xuelin Han; Shuguang Tian; Jingya Zhao; Fangyan Chen; Changjian Zhang; Yansong Sun; Paul E Verweij; Liuyu Huang; Li Han
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

Review 3.  Clinical implications of globally emerging azole resistance in Aspergillus fumigatus.

Authors:  Jacques F Meis; Anuradha Chowdhary; Johanna L Rhodes; Matthew C Fisher; Paul E Verweij
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-12-05       Impact factor: 6.237

4.  Elevated Prevalence of Azole-Resistant Aspergillus fumigatus in Urban versus Rural Environments in the United Kingdom.

Authors:  Thomas R Sewell; Yuyi Zhang; Amelie P Brackin; Jennifer M G Shelton; Johanna Rhodes; Matthew C Fisher
Journal:  Antimicrob Agents Chemother       Date:  2019-08-23       Impact factor: 5.191

Review 5.  The Emerging Threat of Antifungal Resistance in Transplant Infectious Diseases.

Authors:  Ilan S Schwartz; Thomas F Patterson
Journal:  Curr Infect Dis Rep       Date:  2018-02-05       Impact factor: 3.725

6.  Aspergillus fumigatus Clinical Isolates Carrying CYP51A with TR34/L98H/S297T/F495I Substitutions Detected after Four-Year Retrospective Azole Resistance Screening in Brazil.

Authors:  Laís Pontes; Caio Augusto Gualtieri Beraquet; Teppei Arai; Guilherme Leite Pigolli; Luzia Lyra; Akira Watanabe; Maria Luiza Moretti; Angélica Zaninelli Schreiber
Journal:  Antimicrob Agents Chemother       Date:  2020-02-21       Impact factor: 5.191

Review 7.  Emerging threat of triazole-resistant Aspergillus fumigatus.

Authors:  Jeffrey M Rybak; Jarrod R Fortwendel; P David Rogers
Journal:  J Antimicrob Chemother       Date:  2019-04-01       Impact factor: 5.790

8.  Triazole Antifungal Susceptibility Patterns among Aspergillus Species in Québec, Canada.

Authors:  Matthew P Cheng; Alexander Lawandi; Todd C Lee; Philippe J Dufresne; Danila Seidel; Paul E Verweij; Oliver A Cornely; Donald C Sheppard
Journal:  J Clin Microbiol       Date:  2019-05-24       Impact factor: 5.948

9.  Hot topics in antifungal susceptibility testing: A new drug, a bad bug, sweeping caspofungin testing under the rug, and solving the ECV shrug.

Authors:  Shawn R Lockhart; Elizabeth L Berkow
Journal:  Clin Microbiol Newsl       Date:  2016-07

Review 10.  Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.

Authors:  Anna Dudakova; Birgit Spiess; Marut Tangwattanachuleeporn; Christoph Sasse; Dieter Buchheidt; Michael Weig; Uwe Groß; Oliver Bader
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132
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