Literature DB >> 26491154

Growth and Pathogenic Potential of Naturally Selected Reassortants after Coinfection with Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Viruses.

Min-Suk Song1, Yun Hee Baek1, Philippe Noriel Q Pascua1, Hyeok-Il Kwon1, Eun-Ha Kim1, Su-Jin Park1, Se Mi Kim1, Young-Il Kim1, Won-Suk Choi1, Eung-Gook Kim1, Chul-Joong Kim2, Young Ki Choi3.   

Abstract

Coinfection of ferrets with H5N1 and pH1N1 viruses resulted in two predominate genotypes in the lungs containing surface genes of highly pathogenic avian influenza H5N1 virus in the backbone of pandemic H1N1 2009 (pH1N1). Compared to parental strains, these reassortants exhibited increased growth and virulence in vitro and in mice but failed to be transmitted indirectly to naive contact ferrets. Thus, this demonstrates a possible natural reassortment following coinfection as well as the pathogenicity of the potential reassortants.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26491154      PMCID： PMC4702580          DOI： 10.1128/JVI.01572-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses.

Authors:  Yipeng Sun; Kun Qin; Jingjing Wang; Juan Pu; Qingdong Tang; Yanxin Hu; Yuhai Bi; Xueli Zhao; Hanchun Yang; Yuelong Shu; Jinhua Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-28       Impact factor: 11.205

2.  Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model.

Authors:  J Brian Kimble; Erin Sorrell; Hongxia Shao; Philip L Martin; Daniel Roberto Perez
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-05       Impact factor: 11.205

3.  Novel H1N2 swine influenza reassortant strain in pigs derived from the pandemic H1N1/2009 virus.

Authors:  Ana Moreno; Livia Di Trani; Silvia Faccini; Gabriele Vaccari; Daniele Nigrelli; M Beatrice Boniotti; Emiliana Falcone; Arianna Boni; Chiara Chiapponi; Enrica Sozzi; Paolo Cordioli
Journal:  Vet Microbiol       Date:  2010-12-14       Impact factor: 3.293

4.  Increased pathogenicity of a reassortant 2009 pandemic H1N1 influenza virus containing an H5N1 hemagglutinin.

Authors:  Troy D Cline; Erik A Karlsson; Pamela Freiden; Bradley J Seufzer; Jerold E Rehg; Richard J Webby; Stacey Schultz-Cherry
Journal:  J Virol       Date:  2011-09-14       Impact factor: 5.103

5.  Reassortment of pandemic H1N1/2009 influenza A virus in swine.

Authors:  D Vijaykrishna; L L M Poon; H C Zhu; S K Ma; O T W Li; C L Cheung; G J D Smith; J S M Peiris; Y Guan
Journal:  Science       Date:  2010-06-18       Impact factor: 47.728

6.  Virulence and genetic compatibility of polymerase reassortant viruses derived from the pandemic (H1N1) 2009 influenza virus and circulating influenza A viruses.

Authors:  Min-Suk Song; Philippe Noriel Q Pascua; Jun Han Lee; Yun Hee Baek; Kuk Jin Park; Hyeok-il Kwon; Su-Jin Park; Chul-Joong Kim; Hyunggee Kim; Richard J Webby; Robert G Webster; Young Ki Choi
Journal:  J Virol       Date:  2011-04-20       Impact factor: 5.103

7.  Reassorted pandemic (H1N1) 2009 influenza A virus discovered from pigs in Germany.

Authors:  Elke Starick; Elke Lange; Sasan Fereidouni; Claudia Bunzenthal; Robert Höveler; Annette Kuczka; Elisabeth Grosse Beilage; Hans-Peter Hamann; Irene Klingelhöfer; Dirk Steinhauer; Thomas Vahlenkamp; Martin Beer; Timm Harder
Journal:  J Gen Virol       Date:  2011-02-09       Impact factor: 3.891

8.  The pig as a mixing vessel for influenza viruses: Human and veterinary implications.

Authors:  Wenjun Ma; Robert E Kahn; Juergen A Richt
Journal:  J Mol Genet Med       Date:  2008-11-27

9.  Reassortment between avian H5N1 and human H3N2 influenza viruses in ferrets: a public health risk assessment.

Authors:  Sara Jackson; Neal Van Hoeven; Li-Mei Chen; Taronna R Maines; Nancy J Cox; Jacqueline M Katz; Ruben O Donis
Journal:  J Virol       Date:  2009-06-03       Impact factor: 5.103

10.  The polymerase acidic protein gene of influenza a virus contributes to pathogenicity in a mouse model.

Authors:  Min-Suk Song; Philippe Noriel Q Pascua; Jun Han Lee; Yun Hee Baek; Ok-Jun Lee; Chul-Joong Kim; Hyunggee Kim; Richard J Webby; Robert G Webster; Young Ki Choi
Journal:  J Virol       Date:  2009-09-30       Impact factor: 5.103
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  3 in total

Review 1.  Complexities in Ferret Influenza Virus Pathogenesis and Transmission Models.

Authors:  Jessica A Belser; Alissa M Eckert; Terrence M Tumpey; Taronna R Maines
Journal:  Microbiol Mol Biol Rev       Date:  2016-07-13       Impact factor: 11.056

Review 2.  Treating the host response to emerging virus diseases: lessons learned from sepsis, pneumonia, influenza and Ebola.

Authors:  David S Fedson
Journal:  Ann Transl Med       Date:  2016-11

3.  Evidence of exposure of domestic pigs to Highly Pathogenic Avian Influenza H5N1 in Nigeria.

Authors:  Clement Meseko; Anja Globig; Jeremiah Ijomanta; Tony Joannis; Chika Nwosuh; David Shamaki; Timm Harder; Donata Hoffman; Anne Pohlmann; Martin Beer; Thomas Mettenleiter; Elke Starick
Journal:  Sci Rep       Date:  2018-04-12       Impact factor: 4.379
  3 in total

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