Literature DB >> 26491082

Microfracture produces inferior outcomes to other cartilage repair techniques in chondral injuries in the paediatric knee.

Amit Chawla1, Richard Twycross-Lewis2, Nicola Maffulli3.   

Abstract

INTRODUCTION: Chondral injuries are becoming increasingly common in the paediatric knee. First line surgical therapy is usually microfracture (MF), but the emergence of alternative techniques raises the question of what is the optimal treatment in paediatric patients. SOURCES OF DATA: A comprehensive search of PubMed, OVID, Web of Science, SportDiscus and Cochrane databases was performed using the key words 'autologous chondrocyte implantation, MF, mosaicplasty, juvenile, paediatric'. AREAS OF AGREEMENT: Each technique demonstrated a significant post-surgical improvement in clinical outcome scores. However, MF demonstrated poorer outcomes in larger lesions (>3 cm(2)) and shorter durability. AREA OF CONTROVERSY: The quality of the available literature is poor, and there is a lack of comparative trials. GROWING POINTS: The impact of defect characteristics, mechanism of injury and concomitant surgeries should be investigated. AREAS TIMELY FOR DEVELOPING RESEARCH: Appropriately powered randomized controlled trials with suitably long follow up and condition-specific outcome measures should compare different techniques against each other and placebo.
© The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  cartilage repair; microfracture; paediatric

Mesh:

Year:  2015        PMID: 26491082     DOI: 10.1093/bmb/ldv040

Source DB:  PubMed          Journal:  Br Med Bull        ISSN: 0007-1420            Impact factor:   4.291


  4 in total

1.  One-step strategy for cartilage repair using acellular bone matrix scaffold based in situ tissue engineering technique in a preclinical minipig model.

Authors:  Linghui Dai; Zhenming He; Yanfang Jiang; Xin Zhang; Shuang Ren; Jingxian Zhu; Zhenxing Shao; Hongjie Huang; Jiying Zhang; Xin Fu; Xiaoning Duan; Xiaoqing Hu; Yingfang Ao
Journal:  Am J Transl Res       Date:  2019-10-15       Impact factor: 4.060

Review 2.  Articular Cartilage Repair of the Knee in Children and Adolescents.

Authors:  Gian M Salzmann; Philipp Niemeyer; Alfred Hochrein; Martin J Stoddart; Peter Angele
Journal:  Orthop J Sports Med       Date:  2018-03-13

3.  Icariin accelerates cartilage defect repair by promoting chondrogenic differentiation of BMSCs under conditions of oxygen-glucose deprivation.

Authors:  Wang Tang; Hongyi Zhang; Donghua Liu; Feng Jiao
Journal:  J Cell Mol Med       Date:  2021-12-03       Impact factor: 5.310

Review 4.  Current solutions for the treatment of chronic articular cartilage defects in the knee.

Authors:  Mukai Chimutengwende-Gordon; James Donaldson; George Bentley
Journal:  EFORT Open Rev       Date:  2020-03-02
  4 in total

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