| Literature DB >> 2649101 |
H Kurihara1, M Yoshizumi, T Sugiyama, F Takaku, M Yanagisawa, T Masaki, M Hamaoki, H Kato, Y Yazaki.
Abstract
Endothelin is a potent vasoconstrictor peptide produced by vascular endothelial cells. Incubation of the serum-deprived confluent porcine aortic endothelial cells with 10-300 pM TGF-beta 1, resulted in a several fold increase in endothelin mRNA levels with a peak time of 2 h. An enzyme-linked immunosorbent assay revealed that the levels of endothelin in endothelial cell conditioned media was also increased by TGF-beta 1. These results suggest that TGF-beta 1, secreted by activated platelets, is involved not only in wound healing, but in the regulation of local vascular tone by stimulating endothelin production in the endothelial cells.Entities:
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Year: 1989 PMID： 2649101 DOI： 10.1016/0006-291x(89)92270-5
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575