Literature DB >> 2649099

Endothelin and the production of cerebral vasospasm in dogs.

T Asano1, I Ikegaki, Y Suzuki, S Satoh, M Shibuya.   

Abstract

We attempted to determine whether or not endothelin (ET) plays a physiological role in cerebral vasospasm. ET (10(-11) - 3 x 10(-8) M) induced a concentration-dependent contraction in isolated canine basilar arteries. Intracisternal injection of 10 to 1,000 pmol ET into dogs induced a dose-dependent decrease in the basilar artery diameter, as measured angiographically on the 1st day. On the 3rd day after the injection of ET (10 pmol), the diameter of the basilar artery had diminished to 76% of the value seen in the control. There were no effects on blood pressure or heart rate. Thus, ET seems to be a potent constrictor of cerebral arteries in vivo, and these effects are long-lasting.

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Year:  1989        PMID： 2649099     DOI： 10.1016/0006-291x(89)92258-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  24 in total

1.  Endothelin causes contraction of canine and bovine arterial smooth muscle in vitro and in vivo.

Authors:  Y Suzuki; S Satoh; I Ikegaki; T Asano; M Shibuya; K Sugita; K Lederis; O Rorstad
Journal:  Acta Neurochir (Wien)       Date:  1990       Impact factor: 2.216

2.  High sensitivity of porcine cerebral arteries to endothelin.

Authors:  S Fukuda; K Taga; K Shimoji
Journal:  Experientia       Date:  1991-05-15

Review 3.  Vascular plasticity in cerebrovascular disorders.

Authors:  Lars I H Edvinsson; Gro Klitgaard Povlsen
Journal:  J Cereb Blood Flow Metab       Date:  2011-05-11       Impact factor: 6.200

Review 4.  The clinical potential of endothelin receptor antagonists in cardiovascular medicine.

Authors:  C J Ferro; D J Webb
Journal:  Drugs       Date:  1996-01       Impact factor: 9.546

5.  Synergistic internal carotid vasodilator effects of human alpha-calcitonin gene-related peptide and nimodipine in conscious rats.

Authors:  S M Gardiner; A M Compton; T Bennett; P A Kemp; U Ney
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739

6.  Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk.

Authors:  Katsuhito Yasuno; Mehmet Bakırcıoğlu; Siew-Kee Low; Kaya Bilgüvar; Emília Gaál; Ynte M Ruigrok; Mika Niemelä; Akira Hata; Philippe Bijlenga; Hidetoshi Kasuya; Juha E Jääskeläinen; Dietmar Krex; Georg Auburger; Matthias Simon; Boris Krischek; Ali K Ozturk; Shrikant Mane; Gabriel J E Rinkel; Helmuth Steinmetz; Juha Hernesniemi; Karl Schaller; Hitoshi Zembutsu; Ituro Inoue; Aarno Palotie; François Cambien; Yusuke Nakamura; Richard P Lifton; Murat Günel
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-21       Impact factor: 11.205

7.  Endothelin and aneurysmal subarachnoid haemorrhage: a study of subarachnoid cisternal cerebrospinal fluid.

Authors:  P Gaetani; R Rodriguez y Baena; G Grignani; G Spanu; L Pacchiarini; P Paoletti
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-01       Impact factor: 10.154

Review 8.  Endothelins. A potential target for pharmacological intervention in diseases of the elderly.

Authors:  H Lévesque; N Moore; N Cailleux; V Richard; C Thuillez; H Courtois
Journal:  Drugs Aging       Date:  1994-03       Impact factor: 3.923

9.  Increase in choroidal blood flow in rabbits with endothelin-1 induced transient complete obstruction of retinal vessels.

Authors:  T Sato; K Takei; T Nonoyama; T Miyauchi; K Goto; S Hommura
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1995-07       Impact factor: 3.117

10.  Comparison of the contractile effects of endothelin-1 and sarafotoxin S6b in goat isolated cerebral arteries.

Authors:  J B Salom; G Torregrosa; F J Miranda; J A Alabadí; E Alborch
Journal:  Br J Pharmacol       Date:  1992-05       Impact factor: 8.739
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