Hossam El Zomor1, Radwa Nour2, Adel Alieldin3, Hala Taha1, Mohamed M Montasr4, Emad Moussa5, Enas El Nadi6, Sameera Ezzat7, Ahmad S Alfaar8. 1. Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Egyptian National Cancer Institute, Cairo University, Cairo, Egypt. 2. Children's Cancer Hospital Egypt, 57357 Cairo, Egypt. 3. Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Research Institute of Ophthalmology, Cairo, Egypt. 4. Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Tanta University Medical School, Egypt. 5. Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Faculty of Medicine, Menofeyia University, Shebin Elkom, Egypt. 6. Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Beni sweif University Medical School, Beni sweif, Egypt. 7. National Liver Institute, Menofeyia University, Shebin Elkom, Egypt. 8. Children's Cancer Hospital Egypt, 57357 Cairo, Egypt; Cairo University School of Medicine, Cairo, Egypt. Electronic address: ahmadsfar@gmail.com.
Abstract
PURPOSE: To study the presenting signs of Retinoblastoma in Egypt at Egypt's main pediatric oncology referral center. METHODS: This is a prospective descriptive study (hospital-based registry) conducted at Children's Cancer Hospital Egypt between July 2007 and December 2012. RESULTS: Out of 262 patients diagnosed with retinoblastoma, 244 were suffering from intra-ocular disease at presentation. One hundred thirty-nine (57%) patients presented with unilateral disease, while 105 (43%) suffered bilateral disease. The mean age at presentation was 20.6 ± 17 months, averaging 18.87 ± 11.76 months for bilateral and 25.72 ± 18.78 months for unilateral disease. The most common clinical presentation was leukocoria in 180 (73.8%) patients, strabismus in 32 (13.1%) patients and decreased visual acuity in 12 (4.9%) patients. Group D and E disease represented 62% of all affected eyes. Patients with advanced disease (Group C-E) had longer duration of symptoms. CONCLUSION: In Egypt, retinoblastoma patients present more frequently with advanced disease. There is an ever-increasing need to develop a national team dedicated to studying disease significance and formulating a national awareness program.
PURPOSE: To study the presenting signs of Retinoblastoma in Egypt at Egypt's main pediatric oncology referral center. METHODS: This is a prospective descriptive study (hospital-based registry) conducted at Children's Cancer Hospital Egypt between July 2007 and December 2012. RESULTS: Out of 262 patients diagnosed with retinoblastoma, 244 were suffering from intra-ocular disease at presentation. One hundred thirty-nine (57%) patients presented with unilateral disease, while 105 (43%) suffered bilateral disease. The mean age at presentation was 20.6 ± 17 months, averaging 18.87 ± 11.76 months for bilateral and 25.72 ± 18.78 months for unilateral disease. The most common clinical presentation was leukocoria in 180 (73.8%) patients, strabismus in 32 (13.1%) patients and decreased visual acuity in 12 (4.9%) patients. Group D and E disease represented 62% of all affected eyes. Patients with advanced disease (Group C-E) had longer duration of symptoms. CONCLUSION: In Egypt, retinoblastomapatients present more frequently with advanced disease. There is an ever-increasing need to develop a national team dedicated to studying disease significance and formulating a national awareness program.